Several recent studies have described DNA methylation as a new player in the recruitment of transcription factor (TF) in chromatin, highlighting the need to connect the TF binding site (TFBS) in DNA methylation profiles of each. However, while limited TFBS databases for sequence DNA binding motif.
Here, we present MethMotif, TFBS two-dimensional database that records the position weight matrix TFBS together with a certain cell type CpG methylation information is calculated from a combination of CHIP-seq and whole genome bisulfite sequencing datasets. Integrating TFBS motif with DNA methylation TFBS better illustrate the features recognized by TF DNA loci. Specifically, we found that DNA methylation patterns in TFBS can be specific cells (eg MAFF).
Furthermore, for the TF is given, the DNA methylation profile associated with a different distinct DNA binding motifs (eg REST). To date, the database record of more than 500 TFBSs MethMotif count of more than 2000 CHIP-Seq datasets in 11 different cell types.
TADB 2.0: updated database of bacterial type II toxin-antitoxin loci.
Compared with the previous version, smooth database and new data schema is used. With the help of text mining and manual curation, it recorded 6193 TA type II loci in bacteria and archaea replicons 870, including 105 experimentally validated TA loci. In addition, the newly developed TAfinder tool combines search and detection of homologous operon structure, allowing the prediction for type II TA pairs in the bacterial genome sequence. It also helps to investigate the genomic context predicted TA loci for suspected virulence factors, antimicrobial resistance determinants and mobile genetic elements via specific alignments to the public database.
In addition, the module enables TAfinder-Compare compares the presence of TA given locus in the whole genome close relatives. With the latest update, TADB2.0 may provide better support to understand the important role of type II TA systems in prokaryotic life activities.
MethMotif: an integrative cell specific database of transcription factor binding motifs coupled with DNA methylation profiles.
Alea: a toolbox for epigenomics allele-specific analysis.
Assessment of expression and epigenomic Status using sequencing-based methods provide unprecedented opportunity to identify and differences in allele correlated with the status epigenomic. We present Alea, box computing equipment for epigenomics allele-specific analysis, combining data allelic variation within the existing resources, allowing for the identification of a significant relationship between epigenetic modifications and a specific allele variants in human and mouse cells.
Description: A polyclonal antibody against Major allergen Bla g 1.0101. Recognizes Major allergen Bla g 1.0101 from Blattella germanica. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:5000
Description: A polyclonal antibody against Major allergen Bla g 1.0101. Recognizes Major allergen Bla g 1.0101 from Blattella germanica. This antibody is HRP conjugated. Tested in the following application: ELISA
Major allergen Bla g 1.0101 Antibody, FITC conjugated
Description: A polyclonal antibody against Major allergen Bla g 1.0101. Recognizes Major allergen Bla g 1.0101 from Blattella germanica. This antibody is FITC conjugated. Tested in the following application: ELISA
Kinesis Fingertight One-Piece Nut uHP PEEK 10-32; 1/16; Black
Description: A polyclonal antibody against Major allergen Bla g 1.0101. Recognizes Major allergen Bla g 1.0101 from Blattella germanica. This antibody is Biotin conjugated. Tested in the following application: ELISA
Spheroid Microplate 1536 Black with Clear Round bottom
Description: A polyclonal antibody for detection of B2LA1 from Human, Mouse. This B2LA1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human B2LA1 protein
Description: A polyclonal antibody for detection of B2LA1 from Human, Mouse. This B2LA1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human B2LA1 protein
Description: A polyclonal antibody for detection of B2LA1 from Human, Mouse. This B2LA1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human B2LA1 protein
Description: Bladder cancer with bladder tissue array, including urothelial carcinoma,squamous cell carcinoma, adenocarcinoma and normal tissue, pathololy grade, TNM and clinical stage (AJCC 8.0), 12 case/24 cores (1.5mm), replacing BL243
Description: Bladder cancer tissue array with normal bladder tissue, including pathology grade, TNM and clinical stage, 48 cases/48 cores, replaced by BL481c
Rat Bladder PrimaCell2: Normal Bladder Fibroblasts
Description: Bladder cancer with bladder tissue array (2016 WHO classification), including pathology grade, TNM and clinical stage (AJCC 7th edition), 64 cases/192 cores, replacing BL208
Description: A polyclonal antibody against bla. Recognizes bla from Pseudomonas aeruginosa. This antibody is Unconjugated. Tested in the following application: ELISA
Description: A polyclonal antibody against bla. Recognizes bla from Escherichia coli. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:5000
Description: A polyclonal antibody against bla. Recognizes bla from Escherichia coli. This antibody is Unconjugated. Tested in the following application: ELISA
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Rat Bladder PrimaCell2: Normal Bladder Fibroblasts Growth Medium
Description: Bladder cancer tissue array, set 1, containing 24 cases in 48 cores, with normal paired with tumor tissues from the same patients, with grading and TNM staging data.
Description: Bladder tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.
Description: Bladder tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.
Description: Blasticidin S HCl is an antibiotic inhibiting protein synthesis [1]. Blasticidin S is isolated from Streptomyces griseochromogenes and inhibits protein synthesis in both prokaryotic and eukaryotic cells. Blasticidin S HCl is an antibiotic inhibiting protein synthesis.
Description: Blasticidin S HCl is an antibiotic inhibiting protein synthesis [1]. Blasticidin S is isolated from Streptomyces griseochromogenes and inhibits protein synthesis in both prokaryotic and eukaryotic cells. Blasticidin S HCl is an antibiotic inhibiting protein synthesis.
Description: Blasticidin S HCl is an antibiotic inhibiting protein synthesis [1]. Blasticidin S is isolated from Streptomyces griseochromogenes and inhibits protein synthesis in both prokaryotic and eukaryotic cells. Blasticidin S HCl is an antibiotic inhibiting protein synthesis.
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Alea provide customized pipes command-line tool for allele-specific generation sequencing data analysis (CHIP-Seq, RNA-Seq, etc.) that take the raw sequencing data and generate separate alleles tracks ready to be viewed on a genome browser. pipe has been validated using hybrid human and rat CHIP-seq and RNA-seq Data.
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