Metabolomic Approaches to Study Chemical Exposure-Related Metabolism Alterations in Mammalian CellCultures

 

Organic organisms are continuously uncovered to an immense repertoire of molecules that cowl environmental or food-derived molecules and medicines, triggering a steady movement of stimuli-dependent diversifications.

• The variety of those chemical substances in addition to their concentrations contribute to the multiplicity of induced results, together with activation, stimulation, or inhibition of physiological processes and toxicity. Metabolism, because the foremost phenotype and manifestation of life, has confirmed to be immensely delicate and extremely adaptive to chemical stimuli.

• Subsequently, learning the impact of endo- or xenobiotics over mobile metabolism delivers priceless information to apprehend potential mobile exercise of particular person molecules and consider their acute or power advantages and toxicity.

• The event of contemporary metabolomics applied sciences akin to mass spectrometry or nuclear magnetic resonance spectroscopy now gives unprecedented options for the speedy and environment friendly willpower of metabolic profiles of cells and extra complicated organic methods. Mixed with the supply of well-established cell tradition strategies, these analytical strategies seem completely suited to find out the organic exercise and estimate the constructive and adverse results of chemical substances in quite a lot of cell sorts and fashions, even at hardly detectable concentrations.

• Metabolic phenotypes will be estimated from learning intracellular metabolites at homeostasis in vivo, whereas in vitro cell cultures present extra entry to metabolites exchanged with progress media.

• This text discusses analytical options out there for metabolic phenotyping of cell tradition metabolism in addition to the overall metabolomics workflow appropriate for testing the organic exercise of molecular compounds.

• We emphasize how metabolic profiling of cell supernatants and intracellular extracts can ship priceless and complementary insights for evaluating the consequences of xenobiotics on mobile metabolism. We word that the ideas and strategies mentioned primarily for xenobiotics publicity are extensively relevant to drug testing on the whole, together with endobiotics that cowl energetic metabolites, vitamins, peptides and proteins, cytokines, hormones, nutritional vitamins, and so on.

Fluorguard Antifade Mounting Medium
F001	Insitus Biotechnologies	1 ml	EUR 86

EverBrite Mounting Medium with DAPI
23002	Biotium	10mL	EUR 195
Description: Minimum order quantity: 1 unit of 10mL

FluoreGuard Mounting Medium (Hard Set)
FMH030	ScyTek Laboratories	30 ml	EUR 96

FluoreGuard Mounting Medium (Hard Set)
FMH060	ScyTek Laboratories	60 ml	EUR 116

FluoreGuard Mounting Medium (Hard Set)
FMH500	ScyTek Laboratories	500 ml	EUR 327

FluoreGuard Mounting Medium (Hard Set)
FMH999	ScyTek Laboratories	1000 ml	EUR 530

Advantage Mounting Media, for permanent mounting and Coverslipping IHC & special stains from water, 60ml
NB300	Innovex	60 ml	EUR 427

Advantage Mounting Media, for permanent mounting and Coverslipping IHC & special stains from water, 30ml
NB300-30	Innovex	30 ml	EUR 276

Advantage Mounting Media, for permanent mounting and Coverslipping IHC & special stains from water, 125ml
NB300A	Innovex	125 ml	EUR 543

FluoroQuest™ Mounting Medium with DAPI
20004	AAT Bioquest	50 mL	EUR 132

EverBrite Hardset Mounting Medium with DAPI
23004	Biotium	10mL	EUR 213
Description: Minimum order quantity: 1 unit of 10mL

Anti-Fade Mounting Medium (With DAPI)
abx090690-10ml	Abbexa	10 ml	EUR 203

Anti-Fade Mounting Medium (With PI)
abx090691-10ml	Abbexa	10 ml	EUR 203

Mounting Media
99-MED	Fitzgerald	3 ml	EUR 211
Description: Mounting media for use in microscopy preparations

FluorLast? Mounting Media
1213-20	Biovision		EUR 142

Buffered Glycerol Mounting Media
GMM003	ScyTek Laboratories	3 ml	EUR 61

Buffered Glycerol Mounting Media
GMM030	ScyTek Laboratories	30 ml	EUR 72

Buffered Glycerol Mounting Media
GMM500	ScyTek Laboratories	500 ml	EUR 183

Buffered Glycerol Mounting Media
GMM999	ScyTek Laboratories	1000 ml	EUR 260

Permanent Mounting Media (Aqueous)
PMT030	ScyTek Laboratories	30 ml	EUR 109

Permanent Mounting Media (Aqueous)
PMT999	ScyTek Laboratories	1000 ml	EUR 759

ReadiUse™ microscope mounting solution
20009	AAT Bioquest	50 mL	EUR 115

PolyMount Mounting Media MaxTag Histo (OKRA00045)
OKRA00045	Aviva Systems Biology	15 ml	EUR 126
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity:

EC MEDIUM
E05-100-10kg	Alphabiosciences	10 kg	EUR 814

EC MEDIUM
E05-100-2Kg	Alphabiosciences	2 Kg	EUR 216

EC MEDIUM
E05-100-500g	Alphabiosciences	500 g	EUR 95

COLIFORM MEDIUM
C03-127-10kg	Alphabiosciences	10 kg	EUR 1324

COLIFORM MEDIUM
C03-127-2kg	Alphabiosciences	2kg	EUR 327

COLIFORM MEDIUM
C03-127-500g	Alphabiosciences	500 g	EUR 125

HLP MEDIUM
H08-107-10kg	Alphabiosciences	10 kg	EUR 2278

HLP MEDIUM
H08-107-2Kg	Alphabiosciences	2 Kg	EUR 534

HLP MEDIUM
H08-107-500g	Alphabiosciences	500 g	EUR 182

VALI Medium
450	AthenaES	500 ml	EUR 265

DC MEDIUM
D04-117-10kg	Alphabiosciences	10 kg	EUR 1579

DC MEDIUM
D04-117-2kg	Alphabiosciences	2kg	EUR 382

DC MEDIUM
D04-117-500g	Alphabiosciences	500 g	EUR 140

SIM MEDIUM
S19-110-10kg	Alphabiosciences	10 kg	EUR 1021

SIM MEDIUM
S19-110-2kg	Alphabiosciences	2kg	EUR 261

SIM MEDIUM
S19-110-500g	Alphabiosciences	500 g	EUR 107

SOB MEDIUM
S19-124-10kg	Alphabiosciences	10 kg	EUR 965

SOB MEDIUM
S19-124-2kg	Alphabiosciences	2kg	EUR 249

SOB MEDIUM
S19-124-500g	Alphabiosciences	500 g	EUR 104

Advanced Medium
C0003-04	Addexbio	RT 500 mL Bottle	EUR 103

Medium 199
C0012-01	Addexbio	RT 500 mL Bottle	EUR 105

NeuroProgenitor Medium
NM42400	Neuromics	125 ml	EUR 304

Heller's Medium
CP014-010	GenDepot	10X1L	EUR 99

Heller's Medium
CP014-500	GenDepot	50L	EUR 126

Hoagland's Medium
CP015-010	GenDepot	10X1L	EUR 99

Hoagland's Medium
CP015-500	GenDepot	50L	EUR 126

M9CA Medium
SD7025	Bio Basic	250g	EUR 71.75

YM Medium
SD7031	Bio Basic	250g	EUR 70.45

TYGPN Medium
SD7032	Bio Basic	250g	EUR 70.01

M63 Medium
SD7033	Bio Basic	250g	EUR 71.75

M9 Medium
SD7024	Bio Basic	250g	EUR 71.75

A Medium
DJ1018	Bio Basic	100g	EUR 84.8

Fine natural hair brush for mounting sections
PO501	FD Neurotechnologies	each	EUR 67

Insect Cell Medium: TNM-FH Insect Culture Medium
ABP-MED-10001	Allele Biotech	1 liter	Ask for price

Insect Cell Medium: Serum-Free Insect Culture Medium
ABP-MED-10002	Allele Biotech	1 liter	Ask for price

Insect Cell Medium: Grace?s Insect Medium (Unsupplemented)
ABP-MED-10004	Allele Biotech	1 liter	Ask for price

EC MEDIUM, MODIFIED
E05-108-10kg	Alphabiosciences	10 kg	EUR 858

EC MEDIUM, MODIFIED
E05-108-2Kg	Alphabiosciences	2 Kg	EUR 226

EC MEDIUM, MODIFIED
E05-108-500g	Alphabiosciences	500 g	EUR 98

A-1 MEDIUM
A01-116-10kg	Alphabiosciences	10 kg	EUR 1034

A-1 MEDIUM
A01-116-2Kg	Alphabiosciences	2 Kg	EUR 264

A-1 MEDIUM
A01-116-500g	Alphabiosciences	500 g	EUR 108

CARY & BLAIR MEDIUM
C03-131-10kg	Alphabiosciences	10 kg	EUR 2185

CARY & BLAIR MEDIUM
C03-131-2Kg	Alphabiosciences	2 Kg	EUR 514

CARY & BLAIR MEDIUM
C03-131-500g	Alphabiosciences	500 g	EUR 176

FLUID THIOGLYCOLLATE MEDIUM
F06-101-10kg	Alphabiosciences	10 kg	EUR 792

FLUID THIOGLYCOLLATE MEDIUM
F06-101-2kg	Alphabiosciences	2kg	EUR 211

FLUID THIOGLYCOLLATE MEDIUM
F06-101-500g	Alphabiosciences	500 g	EUR 94

TERRIFIC BROTH MEDIUM
T20-114-10kg	Alphabiosciences	10 kg	EUR 675

TERRIFIC BROTH MEDIUM
T20-114-2kg	Alphabiosciences	2kg	EUR 186

TERRIFIC BROTH MEDIUM
T20-114-500g	Alphabiosciences	500 g	EUR 87

THIOGLYCOLLATE MEDIUM, BREWER
T20-118-10kg	Alphabiosciences	10 kg	EUR 1364

THIOGLYCOLLATE MEDIUM, BREWER
T20-118-2kg	Alphabiosciences	2kg	EUR 336

THIOGLYCOLLATE MEDIUM, BREWER
T20-118-500g	Alphabiosciences	500 g	EUR 128

2XYT MICROBIAL MEDIUM
X24-102-10kg	Alphabiosciences	10 kg	EUR 614

2XYT MICROBIAL MEDIUM
X24-102-2Kg	Alphabiosciences	2 Kg	EUR 173

2XYT MICROBIAL MEDIUM
X24-102-500g	Alphabiosciences	500 g	EUR 83

OF BASAL MEDIUM
O15-100-10kg	Alphabiosciences	10 kg	Ask for price

OF BASAL MEDIUM
O15-100-2kg	Alphabiosciences	2kg	Ask for price

OF BASAL MEDIUM
O15-100-500g	Alphabiosciences	500 g	Ask for price

MOTILITY TEST MEDIUM
M13-121-10kg	Alphabiosciences	10 kg	EUR 1528

MOTILITY TEST MEDIUM
M13-121-2Kg	Alphabiosciences	2 Kg	EUR 371

MOTILITY TEST MEDIUM
M13-121-500g	Alphabiosciences	500 g	EUR 137

REINFORCED CLOSTRIDIUM MEDIUM
R18-105-10kg	Alphabiosciences	10 kg	EUR 1194

REINFORCED CLOSTRIDIUM MEDIUM
R18-105-2kg	Alphabiosciences	2kg	EUR 299

REINFORCED CLOSTRIDIUM MEDIUM
R18-105-500g	Alphabiosciences	500 g	EUR 118

Sepadextran-25 Medium
SD25M-100	ABTBeads	100 g	EUR 271

Sepadextran-25 Medium
SD25M-500	ABTBeads	500 g	EUR 1036

Sepadextran-50 Medium
SD50M-100	ABTBeads	100 g	EUR 344

Sepadextran-50 Medium
SD50M-500	ABTBeads	500 g	EUR 1285

Conditional reprogramming: subsequent technology cellculture

Lengthy-term major tradition of mammalian cells has been at all times tough attributable to unavoidable senescence. Standard strategies for producing immortalized cell strains normally require manipulation of genome which ends up in change of vital organic and genetic traits. Not too long ago, conditional reprogramming (CR) emerges as a novel subsequent technology instrument for long-term tradition of major epithelium cells derived from nearly all origins with out alteration of genetic background of major cells.

CR co-cultures major cells with inactivated mouse 3T3-J2 fibroblasts within the presence of RHO-related protein kinase (ROCK) inhibitor Y-27632, enabling major cells to accumulate stem-like traits whereas retain their potential to completely differentiate. With only some years’ growth, CR exhibits broad prospects in purposes in diversified areas together with illness modeling, regenerative drugs, drug analysis, drug discovery in addition to precision drugs. This evaluate is thus to comprehensively summarize and assess present progress in understanding mechanism of CR and its broad purposes, highlighting the worth of CR in each primary and translational researches and discussing the challenges confronted with CR.

Results of Kifunensine on Manufacturing and N-Glycosylation Modification of Butyrylcholinesterase in a Transgenic Rice CellCulture Bioreactor

The manufacturing and N-glycosylation of recombinant human butyrylcholinesterase (BChE), a mannequin extremely glycosylated therapeutic protein, in a transgenic rice cell suspension tradition handled with kifunensine, a powerful α-mannosidase I inhibitor, was studied in a 5 L bioreactor.

A media trade was carried out at day 7 of cultivation by eradicating spent sugar-rich medium (NB+S) and including recent sugar-free (NB-S) medium to induce the rice α-amylase 3D (RAmy3D) promoter to provide rice recombinant human BChE (rrBChE). Utilizing a 1.25X-concentrated sugar-free medium along with an 80% lowered working quantity through the media trade led to a complete energetic rrBChE manufacturing degree of 79 ± 2 µg (g FW)^-1 or 7.5 ± 0.Four mg L^-1 within the presence of kifunensine, which was 1.5-times greater than our earlier bioreactor runs utilizing regular sugar-free (NB-S) media with no kifunensine remedy.

Importantly, the quantity of secreted energetic rrBChE in tradition medium was enhanced within the presence of kifunensine, comprising 44% of the entire energetic rrBChE at day 5 following induction. Coomassie-stained SDS-PAGE gel and Western blot analyses revealed completely different electrophoretic migration of purified rrBChE bands with and with out kifunensine remedy, which was attributed to completely different N-glycoforms. N-Glycosylation evaluation confirmed considerably elevated oligomannose glycans (Man5/6/7/8) in rrBChE handled with kifunensine in comparison with controls. Nonetheless, the mass-transfer limitation of kifunensine was seemingly the main purpose for incomplete inhibition of α-mannosidase I on this bioreactor examine.

ALT. THIOGLYCOLLATE MED.
A01-103-2Kg	Alphabiosciences	2 Kg	Ask for price

ALT. THIOGLYCOLLATE MED.
A01-103-500g	Alphabiosciences	500 g	Ask for price

Bouin's Fluid
BNF125	ScyTek Laboratories	125 ml	EUR 63

Bouin's Fluid
BNF3800	ScyTek Laboratories	1 Gal.	EUR 178

Bouin's Fluid
BNF500	ScyTek Laboratories	500 ml	EUR 80

Bouin's Fluid
BNF999	ScyTek Laboratories	1000 ml	EUR 98

P-Selectin (PF377), RNA Aptamer, unlabeled
AR-298-U	Alpha Diagnostics	Custom	Ask for price

Rat Neuromedin U control/blocking peptide # 2
NMU51-P	Alpha Diagnostics	100 ug	EUR 164

Human Neuromedin U control/blocking peptide # 3
NMU61-P	Alpha Diagnostics	100 ug	EUR 164

Mouse Neuromedin U control/blocking peptide # 4
NMU71-P	Alpha Diagnostics	100 ug	EUR 164

Michel's Transport Fluid
MTF-10000	ScyTek Laboratories	10 L	EUR 762

Michel's Transport Fluid
MTF-20000	ScyTek Laboratories	20 L	EUR 1340

Michel's Transport Fluid
MTF500	ScyTek Laboratories	500 ml	EUR 98

Michel's Transport Fluid
MTF999	ScyTek Laboratories	1000 ml	EUR 127

Ansamitocin P-3
ADC-P-003	Creative Biolabs	unit	Ask for price

Neuromedin U (R/M/H) control/blocking peptides
NMU41-P	Alpha Diagnostics	100 ug	EUR 164

AXYPREP MAG PLASMID KIT- MEDIUM - 384 PREPS
MAG-P-M	CORNING	1/pk	EUR 664
Description: Bioscience Mag Beads; Magnetic Plasmid

HE4, Human ascites fluid
P1438-100	Biovision		EUR 620

HE4, Human ascites fluid
P1438-500	Biovision		EUR 2839

SOF Synthetic Oviduct Fluid.
IVL05-100ML	Caisson Labs	100 ml	EUR 78
Description: Synthetic Oviduct Fluid.

SOF Synthetic Oviduct Fluid.
IVL05-6X100ML	Caisson Labs	6 x 100 ml	EUR 151
Description: Synthetic Oviduct Fluid.

96-Well, pureGrade, Clear Transparent, U-Bottom, 5 Plates/Sleeve, 100/Unit
33-572X	Genesee Scientific	100 plates	EUR 240
Description: Clear for colorimetric assays Non-treated "medium binding" surface 100% high quality polystyrene 330µl well volume Non-sterile 1 lid included in each stack (20 total lids) 20 stacks of 5 plates, pack of 100

Transparent, 96-Well Plates, pureGrade Sterile, Clear U-Bottom 50 Plates/Unit
91-420U	Genesee Scientific	50 plates	EUR 230
Description: Non-treated medium binding surface 100% high quality polystyrene Individually-wrapped plates w/ lids Sterilized via beta-radiation Available in clear, white or black Free from endotoxins, DNase, DNA, RNase; noncytotoxic

Calci-Clear
NAT1312	National Diagnostics	EACH	EUR 78

Calci-Clear
NAT1314	National Diagnostics	EACH	EUR 128

Calci-Clear
NAT1316	National Diagnostics	EACH	EUR 386

Histo-Clear
NAT1330	National Diagnostics	1 US gallon	EUR 154

Histo-Clear
NAT1332	National Diagnostics	5 US gallons	EUR 583

Hepatitis B Virus (HBV) Polymerase (P protein) (A9), RNA Aptamer, unlabeled
AR-233-U	Alpha Diagnostics	Custom	Ask for price

Mouse p/CIP/p300 Control/blocking peptide # 1
CIP11-P	Alpha Diagnostics	100 ug	EUR 164

Mouse p/CIP/p300 Control/blocking peptide # 2
CIP12-P	Alpha Diagnostics	100 ug	EUR 164

YLKKIKNSL, P. falciparum circumsporozoite (CSP 334-342) polypeptide
CSPF15-P	Alpha Diagnostics	1 mg	EUR 286

MICROPLATE, 96 WELL, POLYSTYRENE, CLEAR, ROUND BOTTOM, MEDIUM BINDING, NO LID, NONSTERILE, BULK
3797	CORNING	25/pk	EUR 179
Description: Assay; EIA/RIA - 96 Well

CA-125, Human Ascites Fluid
P1446-10	Biovision		EUR 294

Human Substance P Peptide (amide salt)
SP15-P-1	Alpha Diagnostics	1 mg	EUR 164

Human Substance P Peptide (amide salt)
SP15-P-25	Alpha Diagnostics	25 mg	EUR 529

Human Substance P Peptide (amide salt)
SP15-P-5	Alpha Diagnostics	5 mg	EUR 286

LEYYLREKAKMAGTLIIPES, P. vivax PvMSP-1 peptide 19 (378-397)
MSPV11-P	Alpha Diagnostics	1 mg	EUR 164

SKDQIKKLTSLKNKLERRQN, P. vivax PvMSP-1 peptide 53 (1058-1077)
MSPV12-P	Alpha Diagnostics	1 mg	EUR 164

NFVGKFLELQIPGHTDLLHL, P. vivax PvMSP-1 peptide 4 (78-97)
MSPV13-P	Alpha Diagnostics	1 mg	EUR 164

FNQLMHVINFHYDLLRANVH, P. vivax PvMSP-1 peptide 6 (118-137)
MSPV14-P	Alpha Diagnostics	1 mg	EUR 164

LDMLKKVVLGLWKPLDNIKD, P. vivax PvMSP-1 peptide 8 (158-177)
MSPV15-P	Alpha Diagnostics	1 mg	EUR 164

U-104
9631-25	Biovision		EUR 414

U-104
9631-5	Biovision		EUR 142

U-18666A
9469-100	Biovision		Ask for price

U-18666A
9469-25	Biovision		EUR 457

U-18666A
9469-5	Biovision		EUR 153

Kazinol U
TBW00590	ChemNorm	unit	Ask for price

Gomisin U
TBW01615	ChemNorm	5mg	Ask for price

Ixerin U
TBZ1502	ChemNorm	unit	Ask for price

U-93631
B1851-25	Biovision		EUR 544

U-93631
B1851-5	Biovision		EUR 175

U-73122
B1887-25	Biovision		EUR 544

U-73122
B1887-5	Biovision		EUR 175

U-73343
B1888-5	Biovision		EUR 175

U-74389G
20-abx076631	Abbexa	EUR 314.00 EUR 857.00	100 mg 500 mg

U-0126
20-abx076796	Abbexa	EUR 1121.00 EUR 384.00	25 mg 5 mg

U-101017
HY-19250	MedChemExpress	1mg	EUR 1125

U-73343
HY-108630	MedChemExpress	5mg	EUR 234

U-73122
HY-13419	MedChemExpress	10mM/1mL	EUR 147

U-104
HY-13513	MedChemExpress	10mM/1mL	EUR 113

U 0126
E1B1901	EnoGene	1mg	EUR 161

U-44069
C5324-1	ApexBio	1 mg	EUR 224
Description: EC50: 3 ?M and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectivelyU-44069 is a TP receptor agonist.

U-44069
C5324-10	ApexBio	10 mg	EUR 1442
Description: EC50: 3 ?M and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectivelyU-44069 is a TP receptor agonist.

U-44069
C5324-5	ApexBio	5 mg	EUR 833
Description: EC50: 3 ?M and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectivelyU-44069 is a TP receptor agonist.

U 90042
B7164-10	ApexBio	10 mg	EUR 350

U 90042
B7164-50	ApexBio	50 mg	EUR 1266

U 89843A
B7165-10	ApexBio	10 mg	EUR 292

U 89843A
B7165-50	ApexBio	50 mg	EUR 1054

U 93631
B7170-10	ApexBio	10 mg	EUR 248

U 93631
B7170-100	ApexBio	100 mg	EUR 1407

U 93631
B7170-5	ApexBio	5 mg	EUR 195

U 93631
B7170-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 209

U 93631
B7170-50	ApexBio	50 mg	EUR 864

U 73343
B9013-10	ApexBio	10 mg	EUR 224

U 73343
B9013-25	ApexBio	25 mg	EUR 441

U 73343
B9013-5	ApexBio	5 mg	EUR 154

U-104
A4358-10	ApexBio	10 mg	EUR 108
Description: U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX). Tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the U-104 compound compared with vehicle controls

U-104
A4358-25	ApexBio	25 mg	EUR 171
Description: U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX). Tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the U-104 compound compared with vehicle controls

U-104
A4358-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 108
Description: U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX). Tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the U-104 compound compared with vehicle controls

U-104
A4358-50	ApexBio	50 mg	EUR 270
Description: U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX). Tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the U-104 compound compared with vehicle controls

U-73122
B3422-10	ApexBio	10 mg	EUR 161
Description: U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase).

U-73122
B3422-25	ApexBio	25 mg	EUR 258
Description: U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase).

U-73122
B3422-5	ApexBio	5 mg	EUR 123
Description: U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase).

U-73122
B3422-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 166
Description: U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase).

U 18666A
B6812-10	ApexBio	10 mg	EUR 150
Description: U 18666A is an inhibitor of cholesterol transport and synthesis [1] [2]. Cholesterol is a sterol that biosynthesized by all animal cells and is an essential component of all animal cell membranes that is required to maintain membrane fluidity and structural integrity.

U 18666A
B6812-25	ApexBio	25 mg	EUR 287
Description: U 18666A is an inhibitor of cholesterol transport and synthesis [1] [2]. Cholesterol is a sterol that biosynthesized by all animal cells and is an essential component of all animal cell membranes that is required to maintain membrane fluidity and structural integrity.

U 18666A
B6812-50	ApexBio	50 mg	EUR 473
Description: U 18666A is an inhibitor of cholesterol transport and synthesis [1] [2]. Cholesterol is a sterol that biosynthesized by all animal cells and is an essential component of all animal cell membranes that is required to maintain membrane fluidity and structural integrity.

U 46619
B6890-1	ApexBio	1 mg	EUR 147
Description: EC50: 0.035 ?M for shape change, 0.057 ?M for MLCP, 0.536 ?M for serotonin release, 1.31 ?M for aggregation.

U 46619
B6890-10	ApexBio	10 mg	EUR 830
Description: EC50: 0.035 ?M for shape change, 0.057 ?M for MLCP, 0.536 ?M for serotonin release, 1.31 ?M for aggregation.

U 46619
B6890-5	ApexBio	5 mg	EUR 487
Description: EC50: 0.035 ?M for shape change, 0.057 ?M for MLCP, 0.536 ?M for serotonin release, 1.31 ?M for aggregation.

EC MEDIUM
E05-100-10kg	Alphabiosciences	10 kg	EUR 814

EC MEDIUM
E05-100-2Kg	Alphabiosciences	2 Kg	EUR 216

EC MEDIUM
E05-100-500g	Alphabiosciences	500 g	EUR 95

COLIFORM MEDIUM
C03-127-10kg	Alphabiosciences	10 kg	EUR 1324

COLIFORM MEDIUM
C03-127-2kg	Alphabiosciences	2kg	EUR 327

COLIFORM MEDIUM
C03-127-500g	Alphabiosciences	500 g	EUR 125

HLP MEDIUM
H08-107-10kg	Alphabiosciences	10 kg	EUR 2278

HLP MEDIUM
H08-107-2Kg	Alphabiosciences	2 Kg	EUR 534

HLP MEDIUM
H08-107-500g	Alphabiosciences	500 g	EUR 182

VALI Medium
450	AthenaES	500 ml	EUR 265

DC MEDIUM
D04-117-10kg	Alphabiosciences	10 kg	EUR 1579

DC MEDIUM
D04-117-2kg	Alphabiosciences	2kg	EUR 382

DC MEDIUM
D04-117-500g	Alphabiosciences	500 g	EUR 140

SIM MEDIUM
S19-110-10kg	Alphabiosciences	10 kg	EUR 1021

SIM MEDIUM
S19-110-2kg	Alphabiosciences	2kg	EUR 261

SIM MEDIUM
S19-110-500g	Alphabiosciences	500 g	EUR 107

SOB MEDIUM
S19-124-10kg	Alphabiosciences	10 kg	EUR 965

SOB MEDIUM
S19-124-2kg	Alphabiosciences	2kg	EUR 249

SOB MEDIUM
S19-124-500g	Alphabiosciences	500 g	EUR 104

Advanced Medium
C0003-04	Addexbio	RT 500 mL Bottle	EUR 103

Medium 199
C0012-01	Addexbio	RT 500 mL Bottle	EUR 105

NeuroProgenitor Medium
NM42400	Neuromics	125 ml	EUR 304