Metabolomic Approaches to Study Chemical Exposure-Related Metabolism Alterations in Mammalian CellCultures
Organic organisms are continuously uncovered to an immense repertoire of molecules that cowl environmental or food-derived molecules and medicines, triggering a steady movement of stimuli-dependent diversifications.
- The variety of those chemical substances in addition to their concentrations contribute to the multiplicity of induced results, together with activation, stimulation, or inhibition of physiological processes and toxicity. Metabolism, because the foremost phenotype and manifestation of life, has confirmed to be immensely delicate and extremely adaptive to chemical stimuli.
- Subsequently, learning the impact of endo- or xenobiotics over mobile metabolism delivers priceless information to apprehend potential mobile exercise of particular person molecules and consider their acute or power advantages and toxicity.
- The event of contemporary metabolomics applied sciences akin to mass spectrometry or nuclear magnetic resonance spectroscopy now gives unprecedented options for the speedy and environment friendly willpower of metabolic profiles of cells and extra complicated organic methods. Mixed with the supply of well-established cell tradition strategies, these analytical strategies seem completely suited to find out the organic exercise and estimate the constructive and adverse results of chemical substances in quite a lot of cell sorts and fashions, even at hardly detectable concentrations.
- Metabolic phenotypes will be estimated from learning intracellular metabolites at homeostasis in vivo, whereas in vitro cell cultures present extra entry to metabolites exchanged with progress media.
- This text discusses analytical options out there for metabolic phenotyping of cell tradition metabolism in addition to the overall metabolomics workflow appropriate for testing the organic exercise of molecular compounds.
- We emphasize how metabolic profiling of cell supernatants and intracellular extracts can ship priceless and complementary insights for evaluating the consequences of xenobiotics on mobile metabolism. We word that the ideas and strategies mentioned primarily for xenobiotics publicity are extensively relevant to drug testing on the whole, together with endobiotics that cowl energetic metabolites, vitamins, peptides and proteins, cytokines, hormones, nutritional vitamins, and so on.

![]() Fluorguard Antifade Mounting Medium |
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F001 | Insitus Biotechnologies | 1 ml | EUR 86 |
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23002 | Biotium | 10mL | EUR 195 |
Description: Minimum order quantity: 1 unit of 10mL |
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FMH030 | ScyTek Laboratories | 30 ml | EUR 96 |
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FMH060 | ScyTek Laboratories | 60 ml | EUR 116 |
![]() FluoreGuard Mounting Medium (Hard Set) |
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FMH500 | ScyTek Laboratories | 500 ml | EUR 327 |
![]() FluoreGuard Mounting Medium (Hard Set) |
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FMH999 | ScyTek Laboratories | 1000 ml | EUR 530 |
![]() Advantage Mounting Media, for permanent mounting and Coverslipping IHC & special stains from water, 60ml |
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NB300 | Innovex | 60 ml | EUR 427 |
![]() Advantage Mounting Media, for permanent mounting and Coverslipping IHC & special stains from water, 30ml |
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NB300-30 | Innovex | 30 ml | EUR 276 |
![]() Advantage Mounting Media, for permanent mounting and Coverslipping IHC & special stains from water, 125ml |
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NB300A | Innovex | 125 ml | EUR 543 |
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20004 | AAT Bioquest | 50 mL | EUR 132 |
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23004 | Biotium | 10mL | EUR 213 |
Description: Minimum order quantity: 1 unit of 10mL |
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abx090690-10ml | Abbexa | 10 ml | EUR 203 |
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abx090691-10ml | Abbexa | 10 ml | EUR 203 |
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99-MED | Fitzgerald | 3 ml | EUR 211 |
Description: Mounting media for use in microscopy preparations |
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1213-20 | Biovision | EUR 142 |
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GMM003 | ScyTek Laboratories | 3 ml | EUR 61 |
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GMM030 | ScyTek Laboratories | 30 ml | EUR 72 |
![]() Buffered Glycerol Mounting Media |
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GMM500 | ScyTek Laboratories | 500 ml | EUR 183 |
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GMM999 | ScyTek Laboratories | 1000 ml | EUR 260 |
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PMT030 | ScyTek Laboratories | 30 ml | EUR 109 |
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PMT999 | ScyTek Laboratories | 1000 ml | EUR 759 |
![]() ReadiUse™ microscope mounting solution |
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20009 | AAT Bioquest | 50 mL | EUR 115 |
![]() PolyMount Mounting Media MaxTag Histo (OKRA00045) |
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OKRA00045 | Aviva Systems Biology | 15 ml | EUR 126 |
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity: |
![]() EC MEDIUM |
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E05-100-10kg | Alphabiosciences | 10 kg | EUR 814 |
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E05-100-500g | Alphabiosciences | 500 g | EUR 95 |
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C03-127-10kg | Alphabiosciences | 10 kg | EUR 1324 |
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C03-127-2kg | Alphabiosciences | 2kg | EUR 327 |
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C03-127-500g | Alphabiosciences | 500 g | EUR 125 |
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H08-107-10kg | Alphabiosciences | 10 kg | EUR 2278 |
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H08-107-2Kg | Alphabiosciences | 2 Kg | EUR 534 |
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H08-107-500g | Alphabiosciences | 500 g | EUR 182 |
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450 | AthenaES | 500 ml | EUR 265 |
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D04-117-10kg | Alphabiosciences | 10 kg | EUR 1579 |
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S19-110-10kg | Alphabiosciences | 10 kg | EUR 1021 |
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S19-124-10kg | Alphabiosciences | 10 kg | EUR 965 |
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S19-124-2kg | Alphabiosciences | 2kg | EUR 249 |
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S19-124-500g | Alphabiosciences | 500 g | EUR 104 |
![]() Advanced Medium |
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C0003-04 | Addexbio | RT 500 mL Bottle | EUR 103 |
![]() Medium 199 |
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C0012-01 | Addexbio | RT 500 mL Bottle | EUR 105 |
![]() NeuroProgenitor Medium |
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NM42400 | Neuromics | 125 ml | EUR 304 |
![]() Heller's Medium |
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CP014-010 | GenDepot | 10X1L | EUR 99 |
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CP014-500 | GenDepot | 50L | EUR 126 |
![]() Hoagland's Medium |
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CP015-010 | GenDepot | 10X1L | EUR 99 |
![]() Hoagland's Medium |
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CP015-500 | GenDepot | 50L | EUR 126 |
![]() M9CA Medium |
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SD7025 | Bio Basic | 250g | EUR 71.75 |
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SD7031 | Bio Basic | 250g | EUR 70.45 |
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SD7032 | Bio Basic | 250g | EUR 70.01 |
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SD7033 | Bio Basic | 250g | EUR 71.75 |
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SD7024 | Bio Basic | 250g | EUR 71.75 |
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DJ1018 | Bio Basic | 100g | EUR 84.8 |
![]() Fine natural hair brush for mounting sections |
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PO501 | FD Neurotechnologies | each | EUR 67 |
![]() Insect Cell Medium: TNM-FH Insect Culture Medium |
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ABP-MED-10001 | Allele Biotech | 1 liter | Ask for price |
![]() Insect Cell Medium: Serum-Free Insect Culture Medium |
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ABP-MED-10002 | Allele Biotech | 1 liter | Ask for price |
![]() Insect Cell Medium: Grace?s Insect Medium (Unsupplemented) |
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ABP-MED-10004 | Allele Biotech | 1 liter | Ask for price |
![]() EC MEDIUM, MODIFIED |
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E05-108-10kg | Alphabiosciences | 10 kg | EUR 858 |
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E05-108-2Kg | Alphabiosciences | 2 Kg | EUR 226 |
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E05-108-500g | Alphabiosciences | 500 g | EUR 98 |
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A01-116-10kg | Alphabiosciences | 10 kg | EUR 1034 |
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A01-116-2Kg | Alphabiosciences | 2 Kg | EUR 264 |
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C03-131-10kg | Alphabiosciences | 10 kg | EUR 2185 |
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C03-131-500g | Alphabiosciences | 500 g | EUR 176 |
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F06-101-10kg | Alphabiosciences | 10 kg | EUR 792 |
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F06-101-2kg | Alphabiosciences | 2kg | EUR 211 |
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F06-101-500g | Alphabiosciences | 500 g | EUR 94 |
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T20-114-10kg | Alphabiosciences | 10 kg | EUR 675 |
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T20-114-2kg | Alphabiosciences | 2kg | EUR 186 |
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T20-114-500g | Alphabiosciences | 500 g | EUR 87 |
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T20-118-10kg | Alphabiosciences | 10 kg | EUR 1364 |
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T20-118-2kg | Alphabiosciences | 2kg | EUR 336 |
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T20-118-500g | Alphabiosciences | 500 g | EUR 128 |
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X24-102-10kg | Alphabiosciences | 10 kg | EUR 614 |
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X24-102-2Kg | Alphabiosciences | 2 Kg | EUR 173 |
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X24-102-500g | Alphabiosciences | 500 g | EUR 83 |
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O15-100-10kg | Alphabiosciences | 10 kg | Ask for price |
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O15-100-2kg | Alphabiosciences | 2kg | Ask for price |
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O15-100-500g | Alphabiosciences | 500 g | Ask for price |
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M13-121-10kg | Alphabiosciences | 10 kg | EUR 1528 |
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M13-121-2Kg | Alphabiosciences | 2 Kg | EUR 371 |
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M13-121-500g | Alphabiosciences | 500 g | EUR 137 |
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R18-105-10kg | Alphabiosciences | 10 kg | EUR 1194 |
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R18-105-2kg | Alphabiosciences | 2kg | EUR 299 |
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R18-105-500g | Alphabiosciences | 500 g | EUR 118 |
![]() Sepadextran-25 Medium |
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SD25M-100 | ABTBeads | 100 g | EUR 271 |
![]() Sepadextran-25 Medium |
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SD25M-500 | ABTBeads | 500 g | EUR 1036 |
![]() Sepadextran-50 Medium |
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SD50M-100 | ABTBeads | 100 g | EUR 344 |
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SD50M-500 | ABTBeads | 500 g | EUR 1285 |
Conditional reprogramming: subsequent technology cellculture
Lengthy-term major tradition of mammalian cells has been at all times tough attributable to unavoidable senescence. Standard strategies for producing immortalized cell strains normally require manipulation of genome which ends up in change of vital organic and genetic traits. Not too long ago, conditional reprogramming (CR) emerges as a novel subsequent technology instrument for long-term tradition of major epithelium cells derived from nearly all origins with out alteration of genetic background of major cells.
CR co-cultures major cells with inactivated mouse 3T3-J2 fibroblasts within the presence of RHO-related protein kinase (ROCK) inhibitor Y-27632, enabling major cells to accumulate stem-like traits whereas retain their potential to completely differentiate. With only some years’ growth, CR exhibits broad prospects in purposes in diversified areas together with illness modeling, regenerative drugs, drug analysis, drug discovery in addition to precision drugs. This evaluate is thus to comprehensively summarize and assess present progress in understanding mechanism of CR and its broad purposes, highlighting the worth of CR in each primary and translational researches and discussing the challenges confronted with CR.
Results of Kifunensine on Manufacturing and N-Glycosylation Modification of Butyrylcholinesterase in a Transgenic Rice CellCulture Bioreactor
The manufacturing and N-glycosylation of recombinant human butyrylcholinesterase (BChE), a mannequin extremely glycosylated therapeutic protein, in a transgenic rice cell suspension tradition handled with kifunensine, a powerful α-mannosidase I inhibitor, was studied in a 5 L bioreactor.
A media trade was carried out at day 7 of cultivation by eradicating spent sugar-rich medium (NB+S) and including recent sugar-free (NB-S) medium to induce the rice α-amylase 3D (RAmy3D) promoter to provide rice recombinant human BChE (rrBChE). Utilizing a 1.25X-concentrated sugar-free medium along with an 80% lowered working quantity through the media trade led to a complete energetic rrBChE manufacturing degree of 79 ± 2 µg (g FW)-1 or 7.5 ± 0.Four mg L-1 within the presence of kifunensine, which was 1.5-times greater than our earlier bioreactor runs utilizing regular sugar-free (NB-S) media with no kifunensine remedy.
Importantly, the quantity of secreted energetic rrBChE in tradition medium was enhanced within the presence of kifunensine, comprising 44% of the entire energetic rrBChE at day 5 following induction. Coomassie-stained SDS-PAGE gel and Western blot analyses revealed completely different electrophoretic migration of purified rrBChE bands with and with out kifunensine remedy, which was attributed to completely different N-glycoforms. N-Glycosylation evaluation confirmed considerably elevated oligomannose glycans (Man5/6/7/8) in rrBChE handled with kifunensine in comparison with controls. Nonetheless, the mass-transfer limitation of kifunensine was seemingly the main purpose for incomplete inhibition of α-mannosidase I on this bioreactor examine.
![]() ALT. THIOGLYCOLLATE MED. |
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A01-103-2Kg | Alphabiosciences | 2 Kg | Ask for price |
![]() ALT. THIOGLYCOLLATE MED. |
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A01-103-500g | Alphabiosciences | 500 g | Ask for price |
![]() Bouin's Fluid |
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BNF125 | ScyTek Laboratories | 125 ml | EUR 63 |
![]() Bouin's Fluid |
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BNF3800 | ScyTek Laboratories | 1 Gal. | EUR 178 |
![]() Bouin's Fluid |
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BNF500 | ScyTek Laboratories | 500 ml | EUR 80 |
![]() Bouin's Fluid |
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BNF999 | ScyTek Laboratories | 1000 ml | EUR 98 |
![]() P-Selectin (PF377), RNA Aptamer, unlabeled |
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AR-298-U | Alpha Diagnostics | Custom | Ask for price |
![]() Rat Neuromedin U control/blocking peptide # 2 |
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NMU51-P | Alpha Diagnostics | 100 ug | EUR 164 |
![]() Human Neuromedin U control/blocking peptide # 3 |
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NMU61-P | Alpha Diagnostics | 100 ug | EUR 164 |
![]() Mouse Neuromedin U control/blocking peptide # 4 |
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NMU71-P | Alpha Diagnostics | 100 ug | EUR 164 |
![]() Michel's Transport Fluid |
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MTF-10000 | ScyTek Laboratories | 10 L | EUR 762 |
![]() Michel's Transport Fluid |
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MTF-20000 | ScyTek Laboratories | 20 L | EUR 1340 |
![]() Michel's Transport Fluid |
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MTF500 | ScyTek Laboratories | 500 ml | EUR 98 |
![]() Michel's Transport Fluid |
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MTF999 | ScyTek Laboratories | 1000 ml | EUR 127 |
![]() Ansamitocin P-3 |
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ADC-P-003 | Creative Biolabs | unit | Ask for price |
![]() Neuromedin U (R/M/H) control/blocking peptides |
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NMU41-P | Alpha Diagnostics | 100 ug | EUR 164 |
![]() AXYPREP MAG PLASMID KIT- MEDIUM - 384 PREPS |
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MAG-P-M | CORNING | 1/pk | EUR 664 |
Description: Bioscience Mag Beads; Magnetic Plasmid |
![]() HE4, Human ascites fluid |
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P1438-100 | Biovision | EUR 620 |
![]() HE4, Human ascites fluid |
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P1438-500 | Biovision | EUR 2839 |
![]() SOF Synthetic Oviduct Fluid. |
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IVL05-100ML | Caisson Labs | 100 ml | EUR 78 |
Description: Synthetic Oviduct Fluid. |
![]() SOF Synthetic Oviduct Fluid. |
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IVL05-6X100ML | Caisson Labs | 6 x 100 ml | EUR 151 |
Description: Synthetic Oviduct Fluid. |
![]() 96-Well, pureGrade, Clear Transparent, U-Bottom, 5 Plates/Sleeve, 100/Unit |
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33-572X | Genesee Scientific | 100 plates | EUR 240 |
Description:
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![]() Transparent, 96-Well Plates, pureGrade Sterile, Clear U-Bottom 50 Plates/Unit |
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91-420U | Genesee Scientific | 50 plates | EUR 230 |
Description:
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![]() Calci-Clear |
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NAT1312 | National Diagnostics | EACH | EUR 78 |
![]() Calci-Clear |
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NAT1314 | National Diagnostics | EACH | EUR 128 |
![]() Calci-Clear |
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NAT1316 | National Diagnostics | EACH | EUR 386 |
![]() Histo-Clear |
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NAT1330 | National Diagnostics | 1 US gallon | EUR 154 |
![]() Histo-Clear |
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NAT1332 | National Diagnostics | 5 US gallons | EUR 583 |
![]() Hepatitis B Virus (HBV) Polymerase (P protein) (A9), RNA Aptamer, unlabeled |
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AR-233-U | Alpha Diagnostics | Custom | Ask for price |
![]() Mouse p/CIP/p300 Control/blocking peptide # 1 |
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CIP11-P | Alpha Diagnostics | 100 ug | EUR 164 |
![]() Mouse p/CIP/p300 Control/blocking peptide # 2 |
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CIP12-P | Alpha Diagnostics | 100 ug | EUR 164 |
![]() YLKKIKNSL, P. falciparum circumsporozoite (CSP 334-342) polypeptide |
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CSPF15-P | Alpha Diagnostics | 1 mg | EUR 286 |
![]() MICROPLATE, 96 WELL, POLYSTYRENE, CLEAR, ROUND BOTTOM, MEDIUM BINDING, NO LID, NONSTERILE, BULK |
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3797 | CORNING | 25/pk | EUR 179 |
Description: Assay; EIA/RIA - 96 Well |
![]() CA-125, Human Ascites Fluid |
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P1446-10 | Biovision | EUR 294 |
![]() Human Substance P Peptide (amide salt) |
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SP15-P-1 | Alpha Diagnostics | 1 mg | EUR 164 |
![]() Human Substance P Peptide (amide salt) |
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SP15-P-25 | Alpha Diagnostics | 25 mg | EUR 529 |
![]() Human Substance P Peptide (amide salt) |
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SP15-P-5 | Alpha Diagnostics | 5 mg | EUR 286 |
![]() LEYYLREKAKMAGTLIIPES, P. vivax PvMSP-1 peptide 19 (378-397) |
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MSPV11-P | Alpha Diagnostics | 1 mg | EUR 164 |
![]() SKDQIKKLTSLKNKLERRQN, P. vivax PvMSP-1 peptide 53 (1058-1077) |
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MSPV12-P | Alpha Diagnostics | 1 mg | EUR 164 |
![]() NFVGKFLELQIPGHTDLLHL, P. vivax PvMSP-1 peptide 4 (78-97) |
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MSPV13-P | Alpha Diagnostics | 1 mg | EUR 164 |
![]() FNQLMHVINFHYDLLRANVH, P. vivax PvMSP-1 peptide 6 (118-137) |
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MSPV14-P | Alpha Diagnostics | 1 mg | EUR 164 |
![]() LDMLKKVVLGLWKPLDNIKD, P. vivax PvMSP-1 peptide 8 (158-177) |
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MSPV15-P | Alpha Diagnostics | 1 mg | EUR 164 |
![]() U-104 |
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9631-25 | Biovision | EUR 414 |
![]() U-104 |
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9631-5 | Biovision | EUR 142 |
![]() U-18666A |
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9469-100 | Biovision | Ask for price |
![]() U-18666A |
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9469-25 | Biovision | EUR 457 |
![]() U-18666A |
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9469-5 | Biovision | EUR 153 |
![]() Kazinol U |
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TBW00590 | ChemNorm | unit | Ask for price |
![]() Gomisin U |
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TBW01615 | ChemNorm | 5mg | Ask for price |
![]() Ixerin U |
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TBZ1502 | ChemNorm | unit | Ask for price |
![]() U-93631 |
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B1851-25 | Biovision | EUR 544 |
![]() U-93631 |
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B1851-5 | Biovision | EUR 175 |
![]() U-73122 |
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B1887-25 | Biovision | EUR 544 |
![]() U-73122 |
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B1887-5 | Biovision | EUR 175 |
![]() U-73343 |
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B1888-5 | Biovision | EUR 175 |
![]() U-74389G |
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20-abx076631 | Abbexa |
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![]() U-0126 |
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20-abx076796 | Abbexa |
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![]() U-101017 |
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HY-19250 | MedChemExpress | 1mg | EUR 1125 |
![]() U-73343 |
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HY-108630 | MedChemExpress | 5mg | EUR 234 |
![]() U-73122 |
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HY-13419 | MedChemExpress | 10mM/1mL | EUR 147 |
![]() U-104 |
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HY-13513 | MedChemExpress | 10mM/1mL | EUR 113 |
![]() U 0126 |
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E1B1901 | EnoGene | 1mg | EUR 161 |
![]() U-44069 |
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C5324-1 | ApexBio | 1 mg | EUR 224 |
Description: EC50: 3 ?M and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectivelyU-44069 is a TP receptor agonist. |
![]() U-44069 |
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C5324-10 | ApexBio | 10 mg | EUR 1442 |
Description: EC50: 3 ?M and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectivelyU-44069 is a TP receptor agonist. |
![]() U-44069 |
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C5324-5 | ApexBio | 5 mg | EUR 833 |
Description: EC50: 3 ?M and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectivelyU-44069 is a TP receptor agonist. |
![]() U 90042 |
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B7164-10 | ApexBio | 10 mg | EUR 350 |
![]() U 90042 |
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B7164-50 | ApexBio | 50 mg | EUR 1266 |
![]() U 89843A |
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B7165-10 | ApexBio | 10 mg | EUR 292 |
![]() U 89843A |
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B7165-50 | ApexBio | 50 mg | EUR 1054 |
![]() U 93631 |
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B7170-10 | ApexBio | 10 mg | EUR 248 |
![]() U 93631 |
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B7170-100 | ApexBio | 100 mg | EUR 1407 |
![]() U 93631 |
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B7170-5 | ApexBio | 5 mg | EUR 195 |
![]() U 93631 |
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B7170-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 209 |
![]() U 93631 |
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B7170-50 | ApexBio | 50 mg | EUR 864 |
![]() U 73343 |
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B9013-10 | ApexBio | 10 mg | EUR 224 |
![]() U 73343 |
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B9013-25 | ApexBio | 25 mg | EUR 441 |
![]() U 73343 |
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B9013-5 | ApexBio | 5 mg | EUR 154 |
![]() U-104 |
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A4358-10 | ApexBio | 10 mg | EUR 108 |
Description: U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX). Tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the U-104 compound compared with vehicle controls |
![]() U-104 |
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A4358-25 | ApexBio | 25 mg | EUR 171 |
Description: U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX). Tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the U-104 compound compared with vehicle controls |
![]() U-104 |
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A4358-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
Description: U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX). Tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the U-104 compound compared with vehicle controls |
![]() U-104 |
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A4358-50 | ApexBio | 50 mg | EUR 270 |
Description: U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX). Tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the U-104 compound compared with vehicle controls |
![]() U-73122 |
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B3422-10 | ApexBio | 10 mg | EUR 161 |
Description: U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase). |
![]() U-73122 |
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B3422-25 | ApexBio | 25 mg | EUR 258 |
Description: U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase). |
![]() U-73122 |
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B3422-5 | ApexBio | 5 mg | EUR 123 |
Description: U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase). |
![]() U-73122 |
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B3422-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 166 |
Description: U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase). |
![]() U 18666A |
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B6812-10 | ApexBio | 10 mg | EUR 150 |
Description: U 18666A is an inhibitor of cholesterol transport and synthesis [1] [2]. Cholesterol is a sterol that biosynthesized by all animal cells and is an essential component of all animal cell membranes that is required to maintain membrane fluidity and structural integrity. |
![]() U 18666A |
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B6812-25 | ApexBio | 25 mg | EUR 287 |
Description: U 18666A is an inhibitor of cholesterol transport and synthesis [1] [2]. Cholesterol is a sterol that biosynthesized by all animal cells and is an essential component of all animal cell membranes that is required to maintain membrane fluidity and structural integrity. |
![]() U 18666A |
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B6812-50 | ApexBio | 50 mg | EUR 473 |
Description: U 18666A is an inhibitor of cholesterol transport and synthesis [1] [2]. Cholesterol is a sterol that biosynthesized by all animal cells and is an essential component of all animal cell membranes that is required to maintain membrane fluidity and structural integrity. |
![]() U 46619 |
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B6890-1 | ApexBio | 1 mg | EUR 147 |
Description: EC50: 0.035 ?M for shape change, 0.057 ?M for MLCP, 0.536 ?M for serotonin release, 1.31 ?M for aggregation. |
![]() U 46619 |
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B6890-10 | ApexBio | 10 mg | EUR 830 |
Description: EC50: 0.035 ?M for shape change, 0.057 ?M for MLCP, 0.536 ?M for serotonin release, 1.31 ?M for aggregation. |
![]() U 46619 |
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B6890-5 | ApexBio | 5 mg | EUR 487 |
Description: EC50: 0.035 ?M for shape change, 0.057 ?M for MLCP, 0.536 ?M for serotonin release, 1.31 ?M for aggregation. |
![]() EC MEDIUM |
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E05-100-10kg | Alphabiosciences | 10 kg | EUR 814 |
![]() EC MEDIUM |
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E05-100-2Kg | Alphabiosciences | 2 Kg | EUR 216 |
![]() EC MEDIUM |
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E05-100-500g | Alphabiosciences | 500 g | EUR 95 |
![]() COLIFORM MEDIUM |
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C03-127-10kg | Alphabiosciences | 10 kg | EUR 1324 |
![]() COLIFORM MEDIUM |
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C03-127-2kg | Alphabiosciences | 2kg | EUR 327 |
![]() COLIFORM MEDIUM |
|||
C03-127-500g | Alphabiosciences | 500 g | EUR 125 |
![]() HLP MEDIUM |
|||
H08-107-10kg | Alphabiosciences | 10 kg | EUR 2278 |
![]() HLP MEDIUM |
|||
H08-107-2Kg | Alphabiosciences | 2 Kg | EUR 534 |
![]() HLP MEDIUM |
|||
H08-107-500g | Alphabiosciences | 500 g | EUR 182 |
![]() VALI Medium |
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450 | AthenaES | 500 ml | EUR 265 |
![]() DC MEDIUM |
|||
D04-117-10kg | Alphabiosciences | 10 kg | EUR 1579 |
![]() DC MEDIUM |
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D04-117-2kg | Alphabiosciences | 2kg | EUR 382 |
![]() DC MEDIUM |
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D04-117-500g | Alphabiosciences | 500 g | EUR 140 |
![]() SIM MEDIUM |
|||
S19-110-10kg | Alphabiosciences | 10 kg | EUR 1021 |
![]() SIM MEDIUM |
|||
S19-110-2kg | Alphabiosciences | 2kg | EUR 261 |
![]() SIM MEDIUM |
|||
S19-110-500g | Alphabiosciences | 500 g | EUR 107 |
![]() SOB MEDIUM |
|||
S19-124-10kg | Alphabiosciences | 10 kg | EUR 965 |
![]() SOB MEDIUM |
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S19-124-2kg | Alphabiosciences | 2kg | EUR 249 |
![]() SOB MEDIUM |
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S19-124-500g | Alphabiosciences | 500 g | EUR 104 |
![]() Advanced Medium |
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C0003-04 | Addexbio | RT 500 mL Bottle | EUR 103 |
![]() Medium 199 |
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C0012-01 | Addexbio | RT 500 mL Bottle | EUR 105 |
![]() NeuroProgenitor Medium |
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NM42400 | Neuromics | 125 ml | EUR 304 |