May 26, 2024
bioinfogenome

Level-of-care DNA testing by routinely and sequentially performing extraction, amplification and identification

Fluorescent Lactic Acid Bacteria and Bifidobacteria as Vehicles of DNA Microbial Biosensors

Management and quantification of effector molecules corresponding to heavy metals, toxins or different goal molecules is of nice biotechnological, social and financial curiosity. Microorganisms have regulatory proteins that acknowledge and modify the gene expression within the presence or absence of those compounds (effector molecules) via binding to gene sequences. The affiliation of those recognizing gene sequences to reporter genes will permit the detection of effector molecules of curiosity with excessive sensitivity.

As soon as investigators have these two elements-recognizing gene sequences and reporter genes that emit signals-we want an appropriate automobile to introduce each components. Right here, we propose lactic acid micro organism (LAB) and bifidobacteria as promising service microorganisms for these molecular biosensors. Using fluorescent proteins in addition to food-grade vectors and clustered repeatedly interspaced brief palindromic repeats (CRISPR) are indispensable instruments for introducing biosensors into these microorganisms. Using these LAB and bifidobacteria can be of particular curiosity for learning the intestinal setting or different advanced ecosystems.

The good number of species tailored to many environments, in addition to the opportunity of making use of a number of protocols for his or her transformation with recognizing gene sequences and reporter genes are appreciable benefits. Lastly, an effort should be made to search out recognizable gene sequences.

bioinfogenome
bioinfogenome

DNAAF5 Antibody (HRP)

20-abx308300
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

DNAAF5 Antibody (HRP)

abx308300-100g 100 µg
EUR 362.5

DNAAF5 Antibody (HRP)

abx308300-20g 20 µg
EUR 162.5

DNAAF5 Antibody (HRP)

abx308300-50g 50 µg
EUR 250

DNAAF5 Antibody (FITC)

20-abx308301
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

DNAAF5 Antibody (FITC)

abx308301-100g 100 µg
EUR 362.5

DNAAF5 Antibody (FITC)

abx308301-20g 20 µg
EUR 162.5

DNAAF5 Antibody (FITC)

abx308301-50g 50 µg
EUR 250

DNAAF5 Antibody (Biotin)

20-abx308302
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

DNAAF5 Antibody (Biotin)

abx308302-100g 100 µg
EUR 362.5

DNAAF5 Antibody (Biotin)

abx308302-20g 20 µg
EUR 162.5

DNAAF5 Antibody (Biotin)

abx308302-50g 50 µg
EUR 250

DNAAF5 Polyclonal Antibody

A58814
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  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

DNAAF5 Conjugated Antibody

C42981 100ul
EUR 476.4

DNAAF5 Antibody, HRP conjugated

1-CSB-PA771471LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against DNAAF5. Recognizes DNAAF5 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

DNAAF5 Antibody, FITC conjugated

1-CSB-PA771471LC01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against DNAAF5. Recognizes DNAAF5 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

DNAAF5 Antibody, Biotin conjugated

1-CSB-PA771471LD01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against DNAAF5. Recognizes DNAAF5 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OAGA06580-100UL - DNAAF5 Antibody

OAGA06580-100UL 100ul
EUR 369

DNAAF5 Rabbit Polyclonal Antibody

E10G02198 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

DNAAF5 Polyclonal Antibody, HRP Conjugated

A58817
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  • 100 µg
  • 50 ul
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DNAAF5 Polyclonal Antibody, FITC Conjugated

A58816
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  • 100 µg
  • 50 ul
  • 100 ul

DNAAF5 Polyclonal Antibody, Biotin Conjugated

A58815
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  • 100 µg
  • 50 ul
  • 100 ul

Dnaaf5 (Rat) - 3 unique 27mer siRNA duplexes - 2 nmol each

SR513187 2 nmol Ask for price

DNAAF5 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each

SR310343 2 nmol Ask for price

Dnaaf5 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each

SR420710 2 nmol Ask for price

Human Dynein Assembly Factor 5, Axonemal / HEATR2 (DNAAF5) ELISA Kit

abx387761-96tests 96 tests
EUR 1093.2

Dnaaf5 - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL708859 5 µg/vial Ask for price

Dnaaf5 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL518008 5 µg/vial Ask for price

DNAAF5 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL304136 5 µg/vial Ask for price

DNAAF1 antibody

10R-6890 100 ul
EUR 709
Description: Mouse monoclonal DNAAF1 antibody

DNAAF1 antibody

10R-6892 100 ul
EUR 709
Description: Mouse monoclonal DNAAF1 antibody

DNAAF1 antibody

10R-6893 100 ul
EUR 709
Description: Mouse monoclonal DNAAF1 antibody

DNAAF1 Antibody

DF14672 100ul
EUR 420

DNAAF1 Antibody

DF14672-100ul 100ul
EUR 280

DNAAF1 Antibody

DF14672-200ul 200ul
EUR 350

DNAAF2 Antibody

E40PV8515 50ul
EUR 395
Description: Available in various conjugation types.

DNAAF3 Antibody

20-abx313748
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  • 100 ug
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  • 200 ug
  • 20 ug
  • 50 ug

DNAAF3 Antibody

1-CSB-PA850845LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against DNAAF3. Recognizes DNAAF3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

DNAAF4 Antibody

1-CSB-PA855504LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against DNAAF4. Recognizes DNAAF4 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

DNAAF3 Antibody

abx313748-100g 100 µg
EUR 362.5

DNAAF3 Antibody

abx313748-20g 20 µg
EUR 162.5

DNAAF3 Antibody

abx313748-50g 50 µg
EUR 250

DNAAF5 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector

TR304136 5 µg/vial Ask for price

Dnaaf5 - Rat, 4 unique 29mer shRNA constructs in retroviral untagged vectorr

TR708859 5 µg/vial Ask for price

DNAAF3 Antibody (HRP)

20-abx313749
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

DNAAF3 Antibody (HRP)

abx313749-100g 100 µg
EUR 362.5

DNAAF3 Antibody (HRP)

abx313749-20g 20 µg
EUR 162.5

DNAAF3 Antibody (HRP)

abx313749-50g 50 µg
EUR 250

Dnaaf5 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vectorr

TR518008 5 µg/vial Ask for price

DNAAF3 Antibody (FITC)

20-abx313750
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  • 100 ug
  • 1 mg
  • 200 ug
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DNAAF3 Antibody (FITC)

abx313750-100g 100 µg
EUR 362.5

DNAAF3 Antibody (FITC)

abx313750-20g 20 µg
EUR 162.5

DNAAF3 Antibody (FITC)

abx313750-50g 50 µg
EUR 250

DNAAF3 Antibody (Biotin)

20-abx313751
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  • 100 ug
  • 1 mg
  • 200 ug
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DNAAF3 Antibody (Biotin)

abx313751-100g 100 µg
EUR 362.5

DNAAF3 Antibody (Biotin)

abx313751-20g 20 µg
EUR 162.5

DNAAF3 Antibody (Biotin)

abx313751-50g 50 µg
EUR 250

DNAAF3 Antibody, HRP conjugated

1-CSB-PA850845LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against DNAAF3. Recognizes DNAAF3 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

DNAAF4 Antibody, HRP conjugated

1-CSB-PA855504LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against DNAAF4. Recognizes DNAAF4 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

DNAAF3 Antibody, FITC conjugated

1-CSB-PA850845LC01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against DNAAF3. Recognizes DNAAF3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

DNAAF4 Antibody, FITC conjugated

1-CSB-PA855504LC01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against DNAAF4. Recognizes DNAAF4 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OACA09659-50UG - DNAAF3 Antibody

OACA09659-50UG 50ug
EUR 179

DNAAF3 Antibody, Biotin conjugated

1-CSB-PA850845LD01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against DNAAF3. Recognizes DNAAF3 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

DNAAF4 Antibody, Biotin conjugated

1-CSB-PA855504LD01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against DNAAF4. Recognizes DNAAF4 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OAGA05889-100UL - DNAAF4 Antibody

OAGA05889-100UL 100ul
EUR 369

OACA09659-100UG - DNAAF3 Antibody

OACA09659-100UG 100ug
EUR 319

DNAAF1 Polyclonal Antibody

29897 100ul
EUR 439

DNAAF1 Polyclonal Antibody

29897-100ul 100ul
EUR 302.4

DNAAF1 Polyclonal Antibody

29897-50ul 50ul
EUR 224.4

DNAAF1 Polyclonal Antibody

E916593 100ul
EUR 225
Description: Available in various conjugation types.

DNAAF1 Polyclonal Antibody

E-AB-66867-120uL 120uL
EUR 320
Description: Unconjugated

DNAAF1 Polyclonal Antibody

E-AB-66867-200uL 200uL
EUR 530
Description: Unconjugated

DNAAF1 Polyclonal Antibody

E-AB-66867-60uL 60uL
EUR 200
Description: Unconjugated

DNAAF1 Polyclonal Antibody

E-AB-66867-each each Ask for price
Description: Unconjugated

ARP52548_P050-25UL - DNAAF4 Antibody - middle region

ARP52548_P050-25UL 25ul
EUR 99

ARP75849_P050-25UL - DNAAF1 Antibody - middle region

ARP75849_P050-25UL 25ul
EUR 99

ARP69705_P050-25UL - DNAAF3 Antibody - C-terminal region

ARP69705_P050-25UL 25ul
EUR 99

ARP69706_P050-25UL - DNAAF3 Antibody - C-terminal region

ARP69706_P050-25UL 25ul
EUR 99

ARP52547_P050-25UL - DNAAF4 Antibody - C-terminal region

ARP52547_P050-25UL 25ul
EUR 99

ARP75848_P050-25UL - DNAAF1 Antibody - N-terminal region

ARP75848_P050-25UL 25ul
EUR 99

DNAAF1 Polyclonal Conjugated Antibody

C29897 100ul
EUR 476.4

ARP69705_P050 - DNAAF3 Antibody - C-terminal region (ARP69705_P050)

ARP69705_P050 100ul
EUR 389

ARP69706_P050 - DNAAF3 Antibody - C-terminal region (ARP69706_P050)

ARP69706_P050 100ul
EUR 389

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody

20-abx318218
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody

20-abx112209
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  • 150 ul
  • 50 ul

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody

abx112209-100l 100 µl
EUR 612.5

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody

abx318218-100g 100 µg
EUR 362.5

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody

abx318218-20g 20 µg
EUR 162.5

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody

abx318218-50g 50 µg
EUR 250

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (HRP)

20-abx315110
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
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Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (FITC)

20-abx315111
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (HRP)

abx315110-100g 100 µg
EUR 362.5

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (HRP)

abx315110-20g 20 µg
EUR 162.5

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (HRP)

abx315110-50g 50 µg
EUR 250

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (FITC)

abx315111-100g 100 µg
EUR 362.5

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (FITC)

abx315111-20g 20 µg
EUR 162.5

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (FITC)

abx315111-50g 50 µg
EUR 250

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (Biotin)

20-abx315112
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (Biotin)

abx315112-100g 100 µg
EUR 362.5

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (Biotin)

abx315112-20g 20 µg
EUR 162.5

Dyslexia Susceptibility 1 Candidate 1 / DYX1C1 (DNAAF4) Antibody (Biotin)

abx315112-50g 50 µg
EUR 250

Dnaaf1/ Rat Dnaaf1 ELISA Kit

ELI-50643r 96 Tests
EUR 1063.2

Dnaaf2/ Rat Dnaaf2 ELISA Kit

ELI-08767r 96 Tests
EUR 1063.2

Dnaaf3 (untagged) - Rat dynein, axonemal, assembly factor 3 (Dnaaf3)

RN216952 10 µg Ask for price

DNAAF1 siRNA

20-abx914304
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  • 15 nmol
  • 30 nmol

DNAAF1 siRNA

20-abx914305
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  • 15 nmol
  • 30 nmol

DNAAF2 siRNA

20-abx914306
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  • 15 nmol
  • 30 nmol

DNAAF2 siRNA

20-abx914307
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  • 15 nmol
  • 30 nmol

DNAAF3 siRNA

20-abx914308
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  • 15 nmol
  • 30 nmol

DNAAF3 siRNA

20-abx914309
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  • 15 nmol
  • 30 nmol

DNAAF1 siRNA

20-abx901521
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  • 15 nmol
  • 30 nmol

DNAAF2 siRNA

20-abx901522
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  • 15 nmol
  • 30 nmol

DNAAF3 siRNA

20-abx901523
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  • 15 nmol
  • 30 nmol

Dnaaf3 (myc-DDK-tagged) - Rat dynein, axonemal, assembly factor 3 (Dnaaf3)

RR216952 10 µg Ask for price

DNAAF1 Rabbit pAb

A16593-100ul 100 ul
EUR 369.6

DNAAF1 Rabbit pAb

A16593-200ul 200 ul
EUR 550.8

DNAAF1 Rabbit pAb

A16593-20ul 20 ul
EUR 219.6

DNAAF1 Rabbit pAb

A16593-50ul 50 ul
EUR 267.6

DNAAF1 ELISA KIT|Human

EF004885 96 Tests
EUR 826.8

Dnaaf1 ORF Vector (Rat) (pORF)

ORF066087 1.0 ug DNA
EUR 607.2

Dnaaf2 ORF Vector (Rat) (pORF)

ORF066088 1.0 ug DNA
EUR 607.2

Rat DNAAF1 shRNA Plasmid

20-abx990192
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  • 150 µg
  • 300 µg

Rat DNAAF2 shRNA Plasmid

20-abx990437
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  • 150 µg
  • 300 µg

Rat DNAAF3 shRNA Plasmid

20-abx991254
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  • 150 µg
  • 300 µg

DNAAF1 ORF Vector (Human) (pORF)

ORF018393 1.0 ug DNA Ask for price

DNAAF2 ORF Vector (Human) (pORF)

ORF018394 1.0 ug DNA Ask for price

DNAAF3 ORF Vector (Human) (pORF)

ORF018395 1.0 ug DNA Ask for price

Dnaaf1 3'UTR GFP Stable Cell Line

TU253484 1.0 ml Ask for price

Dnaaf2 3'UTR GFP Stable Cell Line

TU253485 1.0 ml Ask for price

DNAAF3 (GFP-tagged) - Homo sapiens dynein, axonemal, assembly factor 3 (DNAAF3), transcript variant 4

RG234249 10 µg Ask for price

DNAAF3 (GFP-tagged) - Homo sapiens dynein, axonemal, assembly factor 3 (DNAAF3), transcript variant 3

RG234393 10 µg Ask for price

DNAAF3 (GFP-tagged) - Homo sapiens dynein, axonemal, assembly factor 3 (DNAAF3), transcript variant 1

RG234555 10 µg Ask for price

DNAAF3 (untagged) - Homo sapiens dynein, axonemal, assembly factor 3 (DNAAF3), transcript variant 1

SC332446 10 µg Ask for price

DNAAF3 (untagged) - Homo sapiens dynein, axonemal, assembly factor 3 (DNAAF3), transcript variant 3

SC332447 10 µg Ask for price

DNAAF3 (untagged) - Homo sapiens dynein, axonemal, assembly factor 3 (DNAAF3), transcript variant 4

SC332448 10 µg Ask for price

Human DNAAF2 shRNA Plasmid

20-abx960524
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  • 150 µg
  • 300 µg

Human DNAAF1 shRNA Plasmid

20-abx964742
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  • 150 µg
  • 300 µg

Mouse DNAAF3 shRNA Plasmid

20-abx984074
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  • 150 µg
  • 300 µg

Human DNAAF3 shRNA Plasmid

20-abx967554
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  • 150 µg
  • 300 µg

Mouse DNAAF2 shRNA Plasmid

20-abx979964
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  • 150 µg
  • 300 µg

Mouse DNAAF1 shRNA Plasmid

20-abx976562
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  • 150 µg
  • 300 µg

DNAAF3 (Myc-DDK tagged) - Homo sapiens dynein, axonemal, assembly factor 3 (DNAAF3), transcript variant 4

RC234249 10 µg Ask for price

DNAAF3 (Myc-DDK tagged) - Homo sapiens dynein, axonemal, assembly factor 3 (DNAAF3), transcript variant 3

RC234393 10 µg Ask for price

DNAAF3 (Myc-DDK tagged) - Homo sapiens dynein, axonemal, assembly factor 3 (DNAAF3), transcript variant 1

RC234555 10 µg Ask for price

Human DNAAF1 knockout cell line

ABC-KH4268 1 vial Ask for price
Description: Human DNAAF1 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human DNAAF2 knockout cell line

ABC-KH4269 1 vial Ask for price
Description: Human DNAAF2 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human DNAAF3 knockout cell line

ABC-KH4270 1 vial Ask for price
Description: Human DNAAF3 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human DNAAF1 knockdown cell line

ABC-KD4268 1 vial Ask for price
Description: Human DNAAF1 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human DNAAF2 knockdown cell line

ABC-KD4269 1 vial Ask for price
Description: Human DNAAF2 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human DNAAF3 knockdown cell line

ABC-KD4270 1 vial Ask for price
Description: Human DNAAF3 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human DNAAF1 Protein Lysate 20ug

IHUDNAAF1PLLY20UG each
EUR 213
Description: Human DNAAF1 Protein Lysate 20ug

Human DNAAF2 Protein Lysate 20ug

IHUDNAAF2PLLY20UG each
EUR 361
Description: Human DNAAF2 Protein Lysate 20ug

Human DNAAF3 Protein Lysate 20ug

IHUDNAAF3PLLY20UG each
EUR 361
Description: Human DNAAF3 Protein Lysate 20ug

Human DNAAF4 Protein Lysate 20ug

IHUDNAAF4PLLY20UG each
EUR 213
Description: Human DNAAF4 Protein Lysate 20ug

Dnaaf1 Protein Vector (Rat) (pPM-C-HA)

PV264348 500 ng
EUR 723.6

Dnaaf2 Protein Vector (Rat) (pPM-C-HA)

PV264352 500 ng
EUR 1399.2

Dnaaf1 Protein Vector (Rat) (pPB-C-His)

PV264346 500 ng
EUR 723.6

Dnaaf1 Protein Vector (Rat) (pPB-N-His)

PV264347 500 ng
EUR 723.6

Dnaaf1 Protein Vector (Rat) (pPM-C-His)

PV264349 500 ng
EUR 723.6

Dnaaf2 Protein Vector (Rat) (pPB-C-His)

PV264350 500 ng
EUR 1399.2

Irregular Homocysteine Metabolism: An Perception of Alzheimer’s Illness from DNA Methylation

Alzheimer’s illness (AD) is a persistent neurodegenerative illness within the central nervous system that has advanced pathogenesis within the aged. The present evaluation focuses on the epigenetic mechanisms of AD, in response to the newest findings. The most effective-characterized chromatin modifications in epigenetic mechanisms is DNA methylation. Extremely replicable knowledge reveals that AD incidence is usually accompanied by methylation degree adjustments of the AD-related gene.

Homocysteine (Hcy) is just not solely an intermediate product of one-carbon metabolism but in addition an vital impartial danger issue of AD; it may possibly have an effect on the cognitive perform of the mind by altering the one-carbon metabolism and interfering with the DNA methylation course of, leading to cerebrovascular illness. Usually, Hcy could also be an environmental issue that impacts AD by way of the DNA methylation pathway with a collection of adjustments in AD-related substance. This evaluation will think about the relation between DNA methylation and Hcy and take a look at to determine their rule within the pathophysiology of AD.

TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation

 

Hypoxia-inducible components are heterodimeric transcription components that play an important position in a cell’s capability to adapt to low oxygen. The von-Hippel Lindau tumor suppressor (pVHL), acts as a grasp regulator of HIF exercise, and its focusing on of prolyl hydroxylated HIF-α for proteasomal degradation beneath normoxia is considered a significant mechanism for pVHL tumor suppression and mobile response to oxygen.

Whether or not pVHL regulates different targets by the same mechanism is essentially unknown. Right here, we determine TET2/Three as novel targets of pVHL. pVHL induces proteasomal degradation of TET2/3, leading to decreased international 5-hydroxymethylcytosine ranges.

Conserved proline residues inside the LAP/LAP-like motifs of those two proteins are hydroxylated by the prolyl hydroxylase enzymes (PHD2/EGLN1 and PHD3/EGLN3), which is prerequisite for pVHL-mediated degradation. Utilizing zebrafish as a mannequin, we decided that international 5-hydroxymethylcytosine ranges are enhanced in vhl-null, egln1a/b-double null and egln3-null embryos.

Subsequently, we reveal a novel perform for the PHD-pVHL pathway in regulating TET protein stability and exercise. These knowledge prolong our understanding of how TET proteins are regulated and supply new perception into the mechanisms of pVHL in tumor suppression.

Level-of-care DNA testing by routinely and sequentially performing extraction, amplification and identification in a closed-type cassette

  • Nucleic acid detection is vital for scientific diagnostics; nonetheless, it’s difficult to carry out genetic testing on the point-of-care because of the tedious steps concerned in DNA extraction and the chance of cross-contamination from amplicons.
  • To realize a fully-automated and contamination-free nucleic acid detection, we suggest a closed-type cassette system which allows the next steps to be operated routinely and sequentially: pattern preparation based mostly on magnetic beads, goal amplification utilizing multiplex polymerase chain response, and colorimetric detection of amplicons utilizing a serial invasive response coupled with the aggregation of gold nanoparticle probes.
  • The cassette was designed to be spherical and closed, and 10 targets in a pattern might be concurrently detected by the bare eye or utilizing a spectrophotometer within the system.
  • As well as, a cassette-driven system was fabricated to switch reagents between wells, to regulate the temperature of every response, and to sense the color within the detection wells. The cassette system was delicate sufficient to detect 10 genotypes at 5 single nucleotide polymorphism websites associated to the anticoagulant’s utilization, through the use of a 0.5 µL blood pattern.
  • The accuracy of the system was evaluated by detecting 12 entire blood samples, and the outcomes obtained have been according to these obtained utilizing pyrosequencing. The cassette is hermetic and the entire system is absolutely computerized; the one guide operation is the addition of the pattern to the cassette, performing point-of-care genetic testing in a sample-in/answer-out means.

Recombinant Human ORC ubiquitin ligase 1 (OBI1), partial

CSB-EP019878HU1 7525 mg Ask for price

Recombinant Human Histidine--tRNA ligase, cytoplasmic(HARS),partial

AP73159 each Ask for price

Recombinant Human E3 SUMO-protein ligase RanBP2 (RANBP2), partial

CSB-YP019311HU 5952 mg Ask for price

Recombinant Human E3 SUMO-protein ligase RanBP2 (RANBP2), partial

CSB-EP019311HU 2038 mg Ask for price

Recombinant Human E3 SUMO-protein ligase RanBP2(RANBP2),partial

AP77338 each Ask for price

Recombinant Human E3 SUMO-protein ligase RanBP2(RANBP2),partial

AP77339 1mg
EUR 2362

Recombinant Human E3 ubiquitin-protein ligase MIB1 (MIB1), partial

CSB-RP132874h 5314 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase AMFR (AMFR), partial

CSB-MP892337HU1 10165 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase AMFR (AMFR), partial

CSB-EP892337HU1 10249 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase MIB1(MIB1) ,partial

AP72212 1mg
EUR 1978

Recombinant Human Isoleucine--tRNA ligase, cytoplasmic (IARS),partial

CSB-EP336837HU 7175 mg Ask for price

Recombinant Human Histidine--tRNA ligase, cytoplasmic (HARS1),partial

CSB-BP010137HU 57 mg Ask for price

Recombinant Human Isoleucine--tRNA ligase, cytoplasmic (IARS) ,partial

RPC27302-100ug 100ug
EUR 635.8

Recombinant Human Isoleucine--tRNA ligase, cytoplasmic (IARS) ,partial

RPC27302-1mg 1mg
EUR 2885.2

Recombinant Human Isoleucine--tRNA ligase, cytoplasmic (IARS) ,partial

RPC27302-20ug 20ug
EUR 353.4

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial

CSB-YP890933HU 8047 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase RNF13 (RNF13), partial

CSB-EP019831HU1 8892 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase ZFP91 (ZFP91), partial

CSB-EP842694HU1 11097 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase HUWE1 (HUWE1), partial

CSB-EP773604HU 9337 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial

CSB-EP890933HU 4790 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase ZNRF3(ZNRF3),partial

AP73900 1mg
EUR 1978

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial

CSB-BP890933HU 7894 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3) ,partial

RPC28709-100ug 100ug
EUR 926.9

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3) ,partial

RPC28709-1mg 1mg
EUR 2688

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3) ,partial

RPC28709-20ug 20ug
EUR 366.1

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3) ,partial

RPC23738-100ug 100ug
EUR 460.9

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3) ,partial

RPC23738-1mg 1mg
EUR 2237.8

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3) ,partial

RPC23738-20ug 20ug
EUR 258.7

Recombinant Human DNA ligase 1 (LIG1)

CSB-EP012930HU 1617 mg Ask for price

Recombinant Human DNA ligase 1(LIG1)

AP70504 1mg
EUR 1978

Recombinant Human Threonine--tRNA ligase, mitochondrial (TARS2),partial

CSB-EP023132HU 2293 mg Ask for price

Recombinant Human Threonine--tRNA ligase, mitochondrial(TARS2),partial

AP70827 1mg
EUR 1978

Recombinant Human E3 ubiquitin-protein ligase RNF182 (RNF182), partial

CSB-YP822714HU1 12077 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase TRIP12 (TRIP12), partial

CSB-EP617924HU 3735 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase RNF128 (RNF128), partial

CSB-EP837448HU1 11910 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase TRIM11 (TRIM11), partial

CSB-EP856931HU 4448 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase SMURF1 (SMURF1), partial

CSB-EP875720HU1 9200 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase SMURF1 (SMURF1), partial

CSB-EP875720HU1a0 9470 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase TRIM11(TRIM11),partial

AP71491 1mg
EUR 1978

Recombinant Human E3 ubiquitin-protein ligase TRIP12 (TRIP12), partial

CSB-BP617924HU 197 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial (Active)

CSB-MP890933HU 8848 mg Ask for price

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3) ,partial (Active)

RPC27883-100ug 100ug
EUR 514.8

Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3) ,partial (Active)

RPC27883-20ug 20ug
EUR 309.5

Recombinant Human Long-chain-fatty-acid--CoA ligase 5 (ACSL5), partial

CSB-EP891734HU 4800 mg Ask for price

Recombinant Human Long-chain-fatty-acid--CoA ligase 5(ACSL5),partial

AP73919 1mg
EUR 1978

Recombinant Human Probable E3 ubiquitin-protein ligase HERC1 (HERC1), partial

CSB-EP613601HU 7394 mg Ask for price

Recombinant Human Probable E3 ubiquitin-protein ligase HERC1 (HERC1) ,partial

RPC27712-100ug 100ug
EUR 801.9

Recombinant Human Probable E3 ubiquitin-protein ligase HERC1 (HERC1) ,partial

RPC27712-1mg 1mg
EUR 2885.2

Recombinant Human Probable E3 ubiquitin-protein ligase HERC1 (HERC1) ,partial

RPC27712-20ug 20ug
EUR 448.1

Recombinant Human E3 ubiquitin-protein ligase AMFR (AMFR), partial, Biotinylated

CSB-EP892337HU1-B 10223 mg Ask for price

Recombinant Human herpesvirus 1 E3 ubiquitin-protein ligase ICP0 (ICP0), partial

CSB-EP362415HWY 11102 mg Ask for price

Recombinant Mouse Ubiquitin-protein ligase E3A (Ube3a), partial

CSB-YP025488MO 6073 mg Ask for price

Recombinant Mouse Ubiquitin-protein ligase E3A (Ube3a), partial

CSB-EP025488MO 2457 mg Ask for price

Recombinant Mouse Ubiquitin-protein ligase E3A (Ube3a), partial

CSB-MP025488MO 4986 mg Ask for price

Recombinant Mouse Ubiquitin-protein ligase E3A(Ube3a),partial

AP74418 1mg
EUR 2826

Recombinant Mouse Ubiquitin-protein ligase E3A(Ube3a),partial

AP74487 each Ask for price

Recombinant Mouse Long-chain-fatty-acid--CoA ligase 4 (Acsl4), partial

CSB-EP879427MO 7004 mg Ask for price

Recombinant Mouse Long-chain-fatty-acid--CoA ligase 4 (Acsl4) ,partial

RPC28393-100ug 100ug
EUR 801.9

Recombinant Mouse Long-chain-fatty-acid--CoA ligase 4 (Acsl4) ,partial

RPC28393-1mg 1mg
EUR 2885.2

Recombinant Mouse Long-chain-fatty-acid--CoA ligase 4 (Acsl4) ,partial

RPC28393-20ug 20ug
EUR 448.1

Recombinant Mouse E3 ubiquitin-protein ligase UBR1 (Ubr1), partial

CSB-EP025516MO1 11033 mg Ask for price

Recombinant Mouse Isoleucine--tRNA ligase,cytoplasmic (Iars1), partial

CSB-EP803936MO 10503 mg Ask for price

T4 DNA Ligase (Recombinant)

22060706-1 20000 IU
EUR 146.42

Recombinant T4 DNA Ligase

7-03622 20,000IU Ask for price

Recombinant T4 DNA Ligase

7-03623 100,000IU Ask for price

Recombinant T4 DNA Ligase

7-03624 500,000IU Ask for price

T4 DNA Ligase (Recombinant)

abx073011-100000IU 100.000 IU
EUR 610.8

T4 DNA Ligase (Recombinant)

abx073011-20000IU 20.000 IU
EUR 309.6

T4 DNA Ligase (Recombinant)

abx073011-500000IU 500.000 IU
EUR 1846.8

T4 DNA Ligase Recombinant

rAP-1252 Inquiry Ask for price

Recombinant Human Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (SUCLG2),partial

CSB-EP846636HU 4371 mg Ask for price

Recombinant Human Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial(SUCLG2),partial

AP71459 1mg
EUR 1978

Recombinant Human Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (SUCLG2) ,partial

RPC23431-100ug 100ug
EUR 460.9

Recombinant Human Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (SUCLG2) ,partial

RPC23431-1mg 1mg
EUR 2237.8

Recombinant Human Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (SUCLG2) ,partial

RPC23431-20ug 20ug
EUR 258.7

OPCA00149-1MG - Recombinant human DNA ligase 1

OPCA00149-1MG 1mg
EUR 1379

Human DNA ligase 4, LIG4 ELISA KIT

ELI-47684h 96 Tests
EUR 988.8

Human DNA Ligase 4 (LIG4) ELISA Kit

abx388272-96tests 96 tests
EUR 1093.2

OPCA00149-20UG - Recombinant human DNA ligase 1

OPCA00149-20UG 20ug
EUR 218

Recombinant Arabidopsis thaliana E3 SUMO-protein ligase SIZ1 (SIZ1), partial

CSB-EP721197DOA 6994 mg Ask for price

Recombinant Arabidopsis thaliana E3 SUMO-protein ligase SIZ1 (SIZ1) ,partial

RPC27741-100ug 100ug
EUR 801.9

Recombinant Arabidopsis thaliana E3 SUMO-protein ligase SIZ1 (SIZ1) ,partial

RPC27741-1mg 1mg
EUR 2885.2

Recombinant Arabidopsis thaliana E3 SUMO-protein ligase SIZ1 (SIZ1) ,partial

RPC27741-20ug 20ug
EUR 448.1

OPCA00149-100UG - Recombinant human DNA ligase 1

OPCA00149-100UG 100ug
EUR 323

Recombinant (E.Coli) T4 DNA Ligase

RP-374 20 KU
EUR 196.8

DNA Ligase 4 (LIG4) Antibody

20-abx322926
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  • Ask for price
  • 100 ug
  • 50 ug

DNA Ligase 4 (LIG4) Antibody

20-abx324859
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

DNA Ligase 4 (LIG4) Antibody

abx330937-100ul 100 ul
EUR 510

DNA Ligase 4 (LIG4) Antibody

abx034651-400ul 400 ul
EUR 627.6

DNA Ligase 4 (LIG4) Antibody

abx034651-80l 80 µl
EUR 343.2

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