June 19, 2024
[Clinicopathological and molecular genetic features of lipofibromatosis-like neural tumor]

[Clinicopathological and molecular genetic features of lipofibromatosis-like neural tumor]

Goal: To research the clinicopathological and molecular genetic options of lipofibromatosis-like neural tumor(LPF-NT). Strategies: Three instances of LPF-NT in Kids’s Hospital of Fudan College from December 2018 to December 2019 have been analyzed for his or her analysis and differential analysis. Outcomes: One case was male and two instances have been females, all of them aged beneath 1 years outdated. The medical manifestation of LPF-NT was an area infiltrative progress mass in subcutaneous tissue. There have been no particular radiologic options.

Histologically, dense fascicles or compact sheets of spindle cells confirmed infiltration into subcutaneous adipose tissue. Spindle cells displayed a average diploma of nuclear atypia with mitotic exercise cells.Immunohistochemical examine confirmed the tumor cells diffusely expressed S-100 protein, CD34, NTRKI, and pan-TRK. Fluorescence in situ hybridization detected rearrangement of NTRK1 gene in all three instances examined. Conclusions: LPF-NT is a newly named delicate tissue tumor. Histological morphology, immunohistochemistry and molecular detection are useful for the analysis and differential analysis of the illness.

Mannan is a category of cell wall polysaccharides widespread within the plant kingdom. Mannan construction and properties differ in response to species and organ. The cell partitions of cereal grains have been extensively studied because of their position in cereal processing and to their helpful impact on human well being as dietary fiber. Just lately, we confirmed that mannan in wheat (Triticum aestivum) grain endosperm has a linear construction of β-1,4-linked mannose residues.

The purpose of this work was to check the biosynthesis and performance of wheat grain mannan. We confirmed that mannan is deposited within the endosperm early throughout grain improvement, and we recognized candidate mannan biosynthetic genes expressed within the endosperm. The purposeful examine in wheat was unsuccessful due to this fact our greatest candidate genes have been expressed in heterologous programs. The endosperm-specificTaCslA12 gene expressed in Pichia pastoris and in an Arabidopsis thaliana mutant depleted in glucomannan led to the manufacturing of wheat-like linear mannan missing glucose residues and with average acetylation. Subsequently, this gene encodes a mannan synthase and is probably going liable for the synthesis of wheat endosperm mannan.

 

Enhanced Cadmium Accumulation and Tolerance in Transgenic Furry Roots of Solanum nigrum L. Expressing Iron-Regulated Transporter Gene IRT1

Solanum nigrum L., a hyperaccumulator of cadmium (Cd), is thought to be a promising candidate for phytoremediation of heavy metallic air pollution. Within the current examine, the bushy roots of Solanum nigrum L. have been chosen as a mannequin plant system to check the potential utility of Iron-regulated Transporter Gene (IRT1) for the environment friendly phytoremediation of Cd air pollution. The transgenic bushy roots of Solanum nigrum L. expressing the IRT1 gene from Arabidopsis thaliana have been efficiently obtained through the Agrobacterium tumegaciens-mediated methodology. Expression of IRT1 lowered Cd stress-induced phytotoxic results.
Considerably superior root progress, elevated antioxidant enzyme actions, decreased reactive oxygen species (ROS) ranges, and fewer cell apoptosis have been noticed within the transgenic bushy roots of Solanum nigrum L. in comparison with the wild-type strains beneath Cd stress. Enhanced Cd accumulation was additionally carried out within the transgenic bushy roots in comparison with the management (886.eight μg/g vs. 745.zero μg/g). These outcomes present an essential understanding of the Cd tolerance mechanism of transgenic IRT1 bushy roots of Solanum nigrum L., and are of explicit significance to the event of a transgenic candidate for environment friendly phytoremediation course of.
 [Clinicopathological and molecular genetic features of lipofibromatosis-like neural tumor]
[Clinicopathological and molecular genetic features of lipofibromatosis-like neural tumor]

The connection between gastric most cancers and Helicobacter pylori cytotoxin-related gene A genotypes

Gastric most cancers has been referred to as the third main reason behind cancer-related demise on the earth. It’s when most cancers cells kind on the liner of the abdomen. Early signs embrace heartburn, higher belly ache, nausea, and lack of urge for food. Helicobacter pylori is the commonest microscopic creature that has contaminated people worldwide. Greater than half of the world’s inhabitants is contaminated with the bacterium. It’s the important reason behind illnesses similar to abdomen ulcers and abdomen and intestinal issues. H. pylori an infection is expounded to gastric adenocarcinoma and cagA genotype is believed to be associated to most cancers improvement. cytotoxin-associated gene A (CagA) is a 120-145kDa protein encoded on the 40kb cag pathogenicity island (PAI). This examine investigates the affiliation between cagA H. pylori genotypes and gastric most cancers.

Recombinant Human Apoliprotein-J (Clusterin Human Recombinant)

CC014-101 1mg
EUR 13344

Recombinant Human AITRL (AITRL Human)

MBS555501-0005mg 0.005mg
EUR 220

Recombinant Human AITRL (AITRL Human)

MBS555501-002mg 0.02mg
EUR 320

Recombinant Human AITRL (AITRL Human)

MBS555501-5x002mg 5x0.02mg
EUR 1300

TWEAK, recombinant / TNFSF12, recombinant (Human)

054-85 10 μg
EUR 261.36

Recombinant Human PGⅡ

E21-RA29-1 - Ask for price

Recombinant Human GC

MBS7616369-005mg 0.05mg
EUR 405

Recombinant Human GC

MBS7616369-02mg 0.2mg
EUR 760

Recombinant Human GC

MBS7616369-1mg 1mg
EUR 2175

Recombinant Human GC

MBS7616369-5x1mg 5x1mg
EUR 8410

Recombinant Human GH

MBS7608417-005mg 0.05mg
EUR 405

Recombinant Human GH

MBS7608417-02mg 0.2mg
EUR 760

Recombinant Human GH

MBS7608417-1mg 1mg
EUR 2175

Recombinant Human GH

MBS7608417-5x1mg 5x1mg
EUR 8410

Recombinant Human GS

MBS7608504-005mg 0.05mg
EUR 345

Recombinant Human GS

MBS7608504-02mg 0.2mg
EUR 635

Recombinant Human GS

MBS7608504-1mg 1mg
EUR 1800

Recombinant Human GS

MBS7608504-5x1mg 5x1mg
EUR 6955

Recombinant Human C6

MBS7608602-005mg 0.05mg
EUR 345

Recombinant Human C6

MBS7608602-02mg 0.2mg
EUR 635

Recombinant Human C6

MBS7608602-1mg 1mg
EUR 1800

Recombinant Human C6

MBS7608602-5x1mg 5x1mg
EUR 6955

Recombinant Human AR

MBS7612815-005mg 0.05mg
EUR 405

Recombinant Human AR

MBS7612815-02mg 0.2mg
EUR 760

Recombinant Human AR

MBS7612815-1mg 1mg
EUR 2175

Recombinant Human FH

MBS7613325-005mg 0.05mg
EUR 405

Recombinant Human FH

MBS7613325-02mg 0.2mg
EUR 760

Recombinant Human FH

MBS7613325-1mg 1mg
EUR 2175

Recombinant Human FH

MBS7613325-5x1mg 5x1mg
EUR 8410

Recombinant Human HP

MBS7614251-005mg 0.05mg
EUR 405

Recombinant Human HP

MBS7614251-02mg 0.2mg
EUR 760

Recombinant Human HP

MBS7614251-1mg 1mg
EUR 2175

Recombinant Human HP

MBS7614251-5x1mg 5x1mg
EUR 8410

Recombinant Human AR

MBS7612815-5x1mg 5x1mg
EUR 8410

Recombinant Human CP

MBS7613562-005mg 0.05mg
EUR 405

Recombinant Human CP

MBS7613562-02mg 0.2mg
EUR 760

Recombinant Human CP

MBS7613562-1mg 1mg
EUR 2175

Recombinant Human CP

MBS7613562-5x1mg 5x1mg
EUR 8410

Recombinant Human TH

MBS7613924-005mg 0.05mg
EUR 345

Recombinant Human TH

MBS7613924-02mg 0.2mg
EUR 635

Recombinant Human TH

MBS7613924-1mg 1mg
EUR 1800

Recombinant Human TH

MBS7613924-5x1mg 5x1mg
EUR 6955

Recombinant Human C5

MBS7609068-005mg 0.05mg
EUR 345

Recombinant Human C5

MBS7609068-02mg 0.2mg
EUR 635

Recombinant Human C5

MBS7609068-1mg 1mg
EUR 1800

Recombinant Human C5

MBS7609068-5x1mg 5x1mg
EUR 6955

Recombinant Human Rb

MBS7609212-005mg 0.05mg
EUR 470

Recombinant Human Rb

MBS7609212-02mg 0.2mg
EUR 885

Recombinant Human Rb

MBS7609212-1mg 1mg
EUR 2540

Recombinant Human Rb

MBS7609212-5x1mg 5x1mg
EUR 9820

Recombinant Human FH

MBS7609262-005mg 0.05mg
EUR 560

Recombinant Human FH

MBS7609262-02mg 0.2mg
EUR 1060

Recombinant Human FH

MBS7609262-1mg 1mg
EUR 3065

Recombinant Human FH

MBS7609262-5x1mg 5x1mg
EUR 11850

Recombinant Human C4

MBS7609327-005mg 0.05mg
EUR 405

Recombinant Human C4

MBS7609327-02mg 0.2mg
EUR 760

Recombinant Human C4

MBS7609327-1mg 1mg
EUR 2175

Recombinant Human C4

MBS7609327-5x1mg 5x1mg
EUR 8410

Recombinant Human C4

MBS7609328-005mg 0.05mg
EUR 405

Recombinant Human C4

MBS7609328-02mg 0.2mg
EUR 760

Recombinant Human C4

MBS7609328-1mg 1mg
EUR 2175

Recombinant Human C4

MBS7609328-5x1mg 5x1mg
EUR 8410

Recombinant Human GH

P1223-.1 10X10ug
EUR 240
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human GH

P1223-.5 50X10ug
EUR 538.4
Description: Peptides & Proteins|Recombinant Proteins

DR3 (human):Fc (human), (recombinant)

MBS566215-005mg 0.05mg
EUR 585

DR3 (human):Fc (human), (recombinant)

MBS566215-5x005mg 5x0.05mg
EUR 2585

Recombinant Human REC8

MBS7613173-005mg 0.05mg
EUR 405

Recombinant Human REC8

MBS7613173-02mg 0.2mg
EUR 760

Recombinant Human REC8

MBS7613173-1mg 1mg
EUR 2175

Recombinant Human REC8

MBS7613173-5x1mg 5x1mg
EUR 8410

Recombinant Human PRL

AP76222 1mg
EUR 2369

Recombinant Human PRL

CM10-10ug 10ug
EUR 169.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human PRL

CM10-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human PRL

CM10-500ug 500ug
EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human PRL

CM10-50ug 50ug
EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human BAD

7-04501 2µg Ask for price

Recombinant Human BAD

7-04502 5µg Ask for price

Recombinant Human BAD

7-04503 10µg Ask for price

Recombinant Human CD2

7-04717 2µg Ask for price

Recombinant Human CD2

7-04718 5µg Ask for price

Recombinant Human CD2

7-04719 10µg Ask for price

Recombinant Human CD9

7-04741 2µg Ask for price

Recombinant Human CD9

7-04742 5µg Ask for price

Recombinant Human CD9

7-04743 10µg Ask for price

Recombinant Human p53

7-05785 2µg Ask for price

Recombinant Human p53

7-05786 5µg Ask for price

Recombinant Human p53

7-05787 10µg Ask for price

Recombinant Human CSK

Z500098 10 µg
EUR 370
Description: CSK is a cytoplasmic tyrosine kinase that has been shown to downregulate the tyrosine kinase activity of the c-src through tyrosine phosphorylation of the c-src carboxy terminus . A yeast 2-hybrid system has been used to identify proteins associated with CSK. The Src homology-3 (SH3) domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells . This association is highly specific and it is speculated that PEP may be an effector and/or regulator of CSK in T cells and other hemopoietic cells.

Recombinant Human BMX

Z500413 10 µg
EUR 370
Description: Recombinant full-length human BMX was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The BMX gene encodes a non-receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells. The BMX gene is located on chromosomal band Xp22.2 between the DXS197 and DXS207 loci. Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia. BMX is found to induce activation of the Stat signalling pathway.

Recombinant Human EGF

Z100139 1.0 mg
EUR 205
Description: Epidermal growth factor (EGF) is a small mitogenic protein that is thought to be involved in mechanisms such as normal cell growth, oncogenesis, and wound healing. This protein shows both strong sequential and functional homology with human type-alpha transforming growth factor (hTGF alpha), which is a competitor for EGF receptor sites. EGF receptors are expressed in almost all types of tissues. Parietal endoderm, mature skeletal muscles, and hematopoietic tissues do not express the receptor. The EGF receptor, designated HER1, is a 170 kDa transmembrane glycoprotein with a length of 1186 amino acids. It is identical with a previously described glycoprotein called SA-7 (species antigen 7). The extracellular receptor domain has a length of 621 amino acids, including 11 glycosylated asparagine residues and 51 cysteine residues. This domain contains the EGF binding site and also binds mammalian TGF-alpha.

Recombinant Human GH1

Z100265 500 µg
EUR 85
Description: The physiological activity for which growth hormone is best known is the promotion of growth of bone, cartilage, and soft tissues. Detectable levels of growth hormone are found throughout the remainder of adulthood, suggesting other functions in addition to promotion of growth. Growth hormone may be important for the maintenance of lean body mass; most growth-promoting effects of growth hormone are mediated by IGF-1 the synthesis of which is regulated by growth hormone. The biological activities of growth hormone are mediated by receptors belonging to one of the cytokine receptor families. Growth hormone has been shown to be produced by T cells, B cells, and macrophages. In human lymphocytes growth hormone appears to up-regulate its own expression. Growth hormone appears to act as an enhancer of immune responses and is produced in considerable amounts by T helper cells.

Recombinant Human GH1

Z100269 1.0 mg
EUR 150
Description: The physiological activity for which growth hormone is best known is the promotion of growth of bone, cartilage, and soft tissues. Detectable levels of growth hormone are found throughout the remainder of adulthood, suggesting other functions in addition to promotion of growth. Growth hormone may be important for the maintenance of lean body mass; most growth-promoting effects of growth hormone are mediated by IGF-1 the synthesis of which is regulated by growth hormone. The biological activities of growth hormone are mediated by receptors belonging to one of the cytokine receptor families. Growth hormone has been shown to be produced by T cells, B cells, and macrophages. In human lymphocytes growth hormone appears to up-regulate its own expression. Growth hormone appears to act as an enhancer of immune responses and is produced in considerable amounts by T helper cells.

Recombinant Human IL2

Z100485 50 µg
EUR 85
Description: A helical bundle of 4 α-helices, IL2 is an immunoregulatory cytokine that is expressed by CD4+/CD8+ T cells, γδ T cells, B cells, eosinophils and dendritic cells. IL2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. While Human IL2 shares 56% and 66% amino acid sequence identity with mouse and rat IL2, respectively only human and mouse IL2 exhibit cross-species activity. Characteristically, IL2 exerts both autocrine and paracrine activity on T cells. In a regulatory role, IL2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Recombinant Human IL2 is a non-glycosylated polypeptide that contains one intrachain disulfide bond.

Recombinant Human IL2

Z100487 100 µg
EUR 145
Description: A helical bundle of 4 α-helices, IL2 is an immunoregulatory cytokine that is expressed by CD4+/CD8+ T cells, γδ T cells, B cells, eosinophils and dendritic cells. IL2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. While Human IL2 shares 56% and 66% amino acid sequence identity with mouse and rat IL2, respectively only human and mouse IL2 exhibit cross-species activity. Characteristically, IL2 exerts both autocrine and paracrine activity on T cells. In a regulatory role, IL2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Recombinant Human IL2 is a non-glycosylated polypeptide that contains one intrachain disulfide bond.

Recombinant Human IL2

Z100489 1.0 mg
EUR 615
Description: A helical bundle of 4 α-helices, IL2 is an immunoregulatory cytokine that is expressed by CD4+/CD8+ T cells, γδ T cells, B cells, eosinophils and dendritic cells. IL2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. While Human IL2 shares 56% and 66% amino acid sequence identity with mouse and rat IL2, respectively only human and mouse IL2 exhibit cross-species activity. Characteristically, IL2 exerts both autocrine and paracrine activity on T cells. In a regulatory role, IL2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Recombinant Human IL2 is a non-glycosylated polypeptide that contains one intrachain disulfide bond.

Recombinant Human IL3

Z100515 10 µg
EUR 85
Description: IL3 is produced mainly by T cells following cell activation by antigens and mitogens, but also by keratinocytes, natural killer cells, mast cells, endothelial cells, and monocytes. The analysis of bacterial- derived recombinant IL3 shows that glycosylation is not required for activity. IL3 sequences are evolutionarily less well conserved with human and murine IL3 sharing approximately 29% homology (at the protein level) and murine and rat IL3 sharing approximately 54% homology. IL3 receptors are expressed on macrophages, mast cells, eosinophils, megakaryocytes, basophils, bone marrow progenitor cells and various myeloid leukemia cells. Binding of IL3 to its receptor causes specific phosphorylation of a 150 kDa membrane glycoprotein. Recombinant human IL3 is a non-glycosylated globular protein.

Recombinant Human IL3

Z100517 50 µg
EUR 155
Description: IL3 is produced mainly by T cells following cell activation by antigens and mitogens, but also by keratinocytes, natural killer cells, mast cells, endothelial cells, and monocytes. The analysis of bacterial- derived recombinant IL3 shows that glycosylation is not required for activity. IL3 sequences are evolutionarily less well conserved with human and murine IL3 sharing approximately 29% homology (at the protein level) and murine and rat IL3 sharing approximately 54% homology. IL3 receptors are expressed on macrophages, mast cells, eosinophils, megakaryocytes, basophils, bone marrow progenitor cells and various myeloid leukemia cells. Binding of IL3 to its receptor causes specific phosphorylation of a 150 kDa membrane glycoprotein. Recombinant human IL3 is a non-glycosylated globular protein.

Recombinant Human IL3

Z100519 1.0 mg
EUR 2260
Description: IL3 is produced mainly by T cells following cell activation by antigens and mitogens, but also by keratinocytes, natural killer cells, mast cells, endothelial cells, and monocytes. The analysis of bacterial- derived recombinant IL3 shows that glycosylation is not required for activity. IL3 sequences are evolutionarily less well conserved with human and murine IL3 sharing approximately 29% homology (at the protein level) and murine and rat IL3 sharing approximately 54% homology. IL3 receptors are expressed on macrophages, mast cells, eosinophils, megakaryocytes, basophils, bone marrow progenitor cells and various myeloid leukemia cells. Binding of IL3 to its receptor causes specific phosphorylation of a 150 kDa membrane glycoprotein. Recombinant human IL3 is a non-glycosylated globular protein.

Recombinant Human IL4

Z100545 10 µg
EUR 60
Description: IL4 is produced mainly by a sub-population of activated T helper cells which also secrete IL5 and IL6. The biological activities of IL4 are mediated by a specific receptor, the extracellular domain of which is related to the receptors for EPO, IL6, and the beta chain of the IL-2 receptor. IL4 participates in several B-cell activation processes as well as of other cell types. A co-stimulator of DNA-synthesis, IL4 induces the expression of class II MHC molecules on resting B-cells, enhances both secretion and cell surface expression of IgE and IgG1, and also regulates the expression of the low affinity Fc receptor for IgE on both lymphocytes and monocytes. Pre-treatment of macrophages with IL4 prevents the production of IL1, TNF-alpha and prostaglandins in response to activation of the cells by bacterial endotoxins or IFN-gamma.

Recombinant Human IL4

Z100547 100 µg
EUR 470
Description: IL4 is produced mainly by a sub-population of activated T helper cells which also secrete IL5 and IL6. The biological activities of IL4 are mediated by a specific receptor, the extracellular domain of which is related to the receptors for EPO, IL6, and the beta chain of the IL-2 receptor. IL4 participates in several B-cell activation processes as well as of other cell types. A co-stimulator of DNA-synthesis, IL4 induces the expression of class II MHC molecules on resting B-cells, enhances both secretion and cell surface expression of IgE and IgG1, and also regulates the expression of the low affinity Fc receptor for IgE on both lymphocytes and monocytes. Pre-treatment of macrophages with IL4 prevents the production of IL1, TNF-alpha and prostaglandins in response to activation of the cells by bacterial endotoxins or IFN-gamma.

Recombinant Human IL4

Z100549 1.0 mg
EUR 3450
Description: IL4 is produced mainly by a sub-population of activated T helper cells which also secrete IL5 and IL6. The biological activities of IL4 are mediated by a specific receptor, the extracellular domain of which is related to the receptors for EPO, IL6, and the beta chain of the IL-2 receptor. IL4 participates in several B-cell activation processes as well as of other cell types. A co-stimulator of DNA-synthesis, IL4 induces the expression of class II MHC molecules on resting B-cells, enhances both secretion and cell surface expression of IgE and IgG1, and also regulates the expression of the low affinity Fc receptor for IgE on both lymphocytes and monocytes. Pre-treatment of macrophages with IL4 prevents the production of IL1, TNF-alpha and prostaglandins in response to activation of the cells by bacterial endotoxins or IFN-gamma.

Recombinant Human IL6

Z100555 20 µg
EUR 235
Description: IL6 is a pleiotropic cytokine that participates in a wide variety of biological functions such as acute phase response, inflammation, hematopoiesis, bone metabolism and cancer. While produced mainly by stimulated monocytes, fibroblasts and endothelial cells, IL6 is also known to be produced by macrophages, T cells, B lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells and keratinocytes, upon stimulation. Unlike murine IL6 which is inactive on human cells, both human and murine IL6 are equally active on murine cells. The IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids (designated CD126). Recombinant human IL6 is a 21 kDa, non-glycosylated protein that contains two disulfide bridges.

Recombinant Human IL6

Z100557 100 µg
EUR 960
Description: IL6 is a pleiotropic cytokine that participates in a wide variety of biological functions such as acute phase response, inflammation, hematopoiesis, bone metabolism and cancer. While produced mainly by stimulated monocytes, fibroblasts and endothelial cells, IL6 is also known to be produced by macrophages, T cells, B lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells and keratinocytes, upon stimulation. Unlike murine IL6 which is inactive on human cells, both human and murine IL6 are equally active on murine cells. The IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids (designated CD126). Recombinant human IL6 is a 21 kDa, non-glycosylated protein that contains two disulfide bridges.

Recombinant Human IL6

Z100559 10 x 100 µg (Z100557 x 10)
EUR 4215
Description: IL6 is a pleiotropic cytokine that participates in a wide variety of biological functions such as acute phase response, inflammation, hematopoiesis, bone metabolism and cancer. While produced mainly by stimulated monocytes, fibroblasts and endothelial cells, IL6 is also known to be produced by macrophages, T cells, B lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells and keratinocytes, upon stimulation. Unlike murine IL6 which is inactive on human cells, both human and murine IL6 are equally active on murine cells. The IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids (designated CD126). Recombinant human IL6 is a 21 kDa, non-glycosylated protein that contains two disulfide bridges.

Recombinant Human LIF

Z100605 10 µg
EUR 85
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130.

Recombinant Human LIF

Z100607 100 µg
EUR 360
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130.

Recombinant Human LIF

Z100609 1.0 mg
EUR 1500
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130.

Recombinant Human OSM

Z100755 10 µg
EUR 85
Description: Oncostatin M is produced by monocytes and T cells after cell activation, adherent macrophages, and various T cell lines. Oncostatin M is a member of the IL-6-related cytokine subfamily that includes IL-6, IL-11, LIF, CNTF and CT-1. Oncostatin M mediates its bioactivities through two different heterodimer receptors. They both involve gp130 as a signal transducing moiety, which is found also in receptors for a number of other cytokines. When gp130 dimerizes with LIF receptor beta subunit this generates the high affinity type 1 OSM receptor. When gp130 dimerizes with a protein known as OSM receptor beta this generates the type 2 OSM receptor. Both OSM receptors activate the receptor-associated Janus kinases JAK1, JAK2, and TYK2. Signaling also involves the transcriptional activators STAT3 and STAT5b (see also: STAT proteins) were specifically activated through the gp130-OSM-R-beta type II heterocomplex. The signaling pathway differences observed between the common type I LIF/OSM receptor and the specific type II OSM receptor might explain some of the bioactivities specifically displayed by OSM. Oncostatin M inhibits the growth of several tumor cell lines (A375 melanoma, lung carcinomas). The antiproliferative activity of oncostatin M for some cell lines is synergised by TGF-beta and IFN-gamma. It promotes the growth of human fibroblasts, vascular smooth muscle cells, and some normal cell lines. Oncostatin can inhibit the proliferation of murine M1 myeloid leukemic cells and induces their differentiation into macrophage-like cells, a function shared by LIF, G- CSF, and IL-6.

Recombinant Human OSM

Z100757 200 µg
EUR 925
Description: Oncostatin M is produced by monocytes and T cells after cell activation, adherent macrophages, and various T cell lines. Oncostatin M is a member of the IL-6-related cytokine subfamily that includes IL-6, IL-11, LIF, CNTF and CT-1. Oncostatin M mediates its bioactivities through two different heterodimer receptors. They both involve gp130 as a signal transducing moiety, which is found also in receptors for a number of other cytokines. When gp130 dimerizes with LIF receptor beta subunit this generates the high affinity type 1 OSM receptor. When gp130 dimerizes with a protein known as OSM receptor beta this generates the type 2 OSM receptor. Both OSM receptors activate the receptor-associated Janus kinases JAK1, JAK2, and TYK2. Signaling also involves the transcriptional activators STAT3 and STAT5b (see also: STAT proteins) were specifically activated through the gp130-OSM-R-beta type II heterocomplex. The signaling pathway differences observed between the common type I LIF/OSM receptor and the specific type II OSM receptor might explain some of the bioactivities specifically displayed by OSM. Oncostatin M inhibits the growth of several tumor cell lines (A375 melanoma, lung carcinomas). The antiproliferative activity of oncostatin M for some cell lines is synergised by TGF-beta and IFN-gamma. It promotes the growth of human fibroblasts, vascular smooth muscle cells, and some normal cell lines. Oncostatin can inhibit the proliferation of murine M1 myeloid leukemic cells and induces their differentiation into macrophage-like cells, a function shared by LIF, G- CSF, and IL-6.

Recombinant Human OSM

Z100759 1.0 mg
EUR 2015
Description: Oncostatin M is produced by monocytes and T cells after cell activation, adherent macrophages, and various T cell lines. Oncostatin M is a member of the IL-6-related cytokine subfamily that includes IL-6, IL-11, LIF, CNTF and CT-1. Oncostatin M mediates its bioactivities through two different heterodimer receptors. They both involve gp130 as a signal transducing moiety, which is found also in receptors for a number of other cytokines. When gp130 dimerizes with LIF receptor beta subunit this generates the high affinity type 1 OSM receptor. When gp130 dimerizes with a protein known as OSM receptor beta this generates the type 2 OSM receptor. Both OSM receptors activate the receptor-associated Janus kinases JAK1, JAK2, and TYK2. Signaling also involves the transcriptional activators STAT3 and STAT5b (see also: STAT proteins) were specifically activated through the gp130-OSM-R-beta type II heterocomplex. The signaling pathway differences observed between the common type I LIF/OSM receptor and the specific type II OSM receptor might explain some of the bioactivities specifically displayed by OSM. Oncostatin M inhibits the growth of several tumor cell lines (A375 melanoma, lung carcinomas). The antiproliferative activity of oncostatin M for some cell lines is synergised by TGF-beta and IFN-gamma. It promotes the growth of human fibroblasts, vascular smooth muscle cells, and some normal cell lines. Oncostatin can inhibit the proliferation of murine M1 myeloid leukemic cells and induces their differentiation into macrophage-like cells, a function shared by LIF, G- CSF, and IL-6.

Recombinant Human PTH

Z100775 100 µg
EUR 85
Description: Parathyroid hormone is a circulating hormone that acts as the central regulator of calcium metabolism by directly targeting bone, kidney, and intestine. The classical concept of PTH action is that it regulates serum calcium levels by stimulating bone resorption. However, intermittent administration of PTH selectively stimulates bone formation. It is now known that PTH binds to its receptor PTH1R, and activates the G protein alpha subunits. Besides PKA and PKC activation, PTH also regulates MAPKs including p42/p44 ERKs, p38, and c-Jun N-terminal kinase subtypes.

Recombinant Human PTH

Z100777 1.0 mg
EUR 705
Description: Parathyroid hormone is a circulating hormone that acts as the central regulator of calcium metabolism by directly targeting bone, kidney, and intestine. The classical concept of PTH action is that it regulates serum calcium levels by stimulating bone resorption. However, intermittent administration of PTH selectively stimulates bone formation. It is now known that PTH binds to its receptor PTH1R, and activates the G protein alpha subunits. Besides PKA and PKC activation, PTH also regulates MAPKs including p42/p44 ERKs, p38, and c-Jun N-terminal kinase subtypes.

Recombinant Human PTH

Z100779 2.0 mg
EUR 1140
Description: Parathyroid hormone is a circulating hormone that acts as the central regulator of calcium metabolism by directly targeting bone, kidney, and intestine. The classical concept of PTH action is that it regulates serum calcium levels by stimulating bone resorption. However, intermittent administration of PTH selectively stimulates bone formation. It is now known that PTH binds to its receptor PTH1R, and activates the G protein alpha subunits. Besides PKA and PKC activation, PTH also regulates MAPKs including p42/p44 ERKs, p38, and c-Jun N-terminal kinase subtypes.

Recombinant Human SCF

Z100815 10 µg
EUR 115
Description: SCF is a stromal cell-derived cytokine synthesized by fibroblasts and other cell types. SCF promotes proliferation and early differentiation of cells at the level of multipotent stem cells. It has been suggested that SCF is essential for optimal production of various hematopoietic lineages, mainly because of its ability to prevent apoptosis when co-stimulated with other cytokines. The receptor for SCF, designated SCFR (CD117) is the oncogene designated as KIT. The biological activities of SCF are considerably synergised by colony stimulating factors; GM-CSF and G-CSF, and by IL7, EPO and some other growth and differentiation factors. In combination with IL7, SCF stimulates the proliferation of pre-B cells. SCF is also a potent chemoattractant for cells expressing the kit receptor. Recombinant Human SCF is a monomeric protein that contains intra-chain disulfide bonds.

Recombinant Human SCF

Z100817 100 µg
EUR 480
Description: SCF is a stromal cell-derived cytokine synthesized by fibroblasts and other cell types. SCF promotes proliferation and early differentiation of cells at the level of multipotent stem cells. It has been suggested that SCF is essential for optimal production of various hematopoietic lineages, mainly because of its ability to prevent apoptosis when co-stimulated with other cytokines. The receptor for SCF, designated SCFR (CD117) is the oncogene designated as KIT. The biological activities of SCF are considerably synergised by colony stimulating factors; GM-CSF and G-CSF, and by IL7, EPO and some other growth and differentiation factors. In combination with IL7, SCF stimulates the proliferation of pre-B cells. SCF is also a potent chemoattractant for cells expressing the kit receptor. Recombinant Human SCF is a monomeric protein that contains intra-chain disulfide bonds.

Recombinant Human SCF

Z100819 10 x 100 µg (Z100817 x 10)
EUR 2350
Description: SCF is a stromal cell-derived cytokine synthesized by fibroblasts and other cell types. SCF promotes proliferation and early differentiation of cells at the level of multipotential stem cells. It has been suggested that SCF is essential for optimal production of various hematopoietic lineages, mainly because of its ability to prevent apoptosis when it co-stimulates with other cytokines. The receptor for SCF, designated SCFR(CD117), is the oncogene designated as KIT. The biological activities of SCF are synergised considerably by colony stimulating factors GM-CSF and G-CSF, and also by IL-7, Epo and some other growth and differentiation factors. In combination with IL-7, SCF stimulates the proliferation of pre-B cells. SCF is also a potent chemoattractant for cells (see also: Chemotaxis), for example, mast cells expressing the kit receptor. One response to SCF in these cells is a characteristic rearrangement of the actin filaments of the cytoskeleton.

Recombinant Human TNF

Z100855 50 µg
EUR 85
Description: Tumor Necrosis Factor is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides although cells expressing CD8(+) secrete little or no TNF-alpha. In addition, TNF is secreted by peripheral neutrophilic granulocytes and by a number of transformed cell lines that include those of astrocytes, microglial cells, smooth muscle cells and fibroblasts. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL2, GM-CSF, SP, Bradykinin, Immune complexes, inhibitors of cyclooxygenase and platelet activating factor. TNF-alpha shares approximately 30% homology with TNF-beta. Human TNF-alpha is a non-glycosylated protein of 17.6 kDa.

Recombinant Human TNF

Z100857 100 µg
EUR 135
Description: Tumor Necrosis Factor is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides although cells expressing CD8(+) secrete little or no TNF-alpha. In addition, TNF is secreted by peripheral neutrophilic granulocytes and by a number of transformed cell lines that include those of astrocytes, microglial cells, smooth muscle cells and fibroblasts. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL2, GM-CSF, SP, Bradykinin, Immune complexes, inhibitors of cyclooxygenase and platelet activating factor. TNF-alpha shares approximately 30% homology with TNF-beta. Human TNF-alpha is a non-glycosylated protein of 17.6 kDa.

Recombinant Human TNF

Z100859 1.0 mg
EUR 630
Description: Tumor Necrosis Factor is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides. Cells expressing CD4 secrete TNF-alpha while CD8(+) cells secrete little or no TNF-alpha. Stimulated peripheral neutrophilic granulocytes but also unstimulated cells and also a number of transformed cell lines, astrocytes, microglial cells, smooth muscle cells, and fibroblasts also secrete TNF. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL-2, GM-CSF, SP, Bradykinin, Immune complexes, inhibitors of cyclooxygenase and PAF (platelet activating factor). Human TNF-alpha is a non-glycosylated protein of 17 kDa and a length of 157 amino acids. Murine TNF-alpha is N-glycosylated. Homology with TNF-beta is approximately 30%. TNF-alpha forms dimers and trimers.

Recombinant Human LTA

Z100865 20 µg
EUR 85
Description: TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells.
For this goal, 65 abdomen biopsies of the gastric most cancers sufferers and 100 saliva samples have been collected from wholesome and H. pylori-infected people. Then genomic DNA was purified and Polymerase Chain Response (PCR) was carried out for the studied gene utilizing particular primers. The presence of H. pylori was investigated by PCR and a pair of particular primers for a protected area within the bacterium glmM gene. Then cagA+ and cagA- genotypes frequencies have been decided in H. pylori-infected instances. Statistical evaluation confirmed that there have been important variations between wholesome and diseased ones for genotypes cagA+ and cagA-. Then the cagA+ is usually a danger issue genotype for gastric most cancers.

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