BACKGROUND
Visualization and molecular profiling data analysis together with biological tissue can provide new mechanistic insight into the biological function. At present, it is possible to visualize high-throughput of data over the network layout has been determined, but they are not always suitable for the tasks of data analysis are given. A network layout based simultaneously on the network structure and associated multidimensional data may be advantageous for data visualization and analysis in some cases.
RESULTS
We develop Cytoscape application, which allows to build a biological network layout based on data from the molecular profile is imported as the values of the attribute node. Dedal is 3 Cytoscape application, which uses an algorithm of linear and non-linear dimension reduction for network layout generate data-driven based on the multidimensional data (usually the expression of genes). tools Dedal some data pre-processing and post-processing layout step as a continuous morphing between two arbitrary network layout and align the network layout with respect to each other by rotating and mirroring.
The combination of all of these functions facilitate the creation of the network layout insight which represents both structural network features and patterns of correlations in multivariate data. We demonstrate the added value of the application Dedal in several practical applications, including tissue samples large protein-protein interactions.
DeDaL: Cytoscape 3 app for producing and morphing data-driven and structure-driven network layouts.
Detection of miRNA regulatory effects on triple negative breast cancer transcriptome.
Identify key microRNAs (miRNAs) contributing to the origin and development of certain diseases is the focus of much recent research. We introduce here the rank-based algorithms for detecting miRNA regulatory activity in cancer tissue samples revealed that combining the measurements of gene and the expression levels of miRNA and target sequence-based prediction. This method is designed to detect modest but coordinated changes in expression of the target gene-sequence predicted based. We apply an algorithm to a cohort of 129 breast tumor and the healthy tissue and shown to be effective in identifying functional miRNAs may be involved in disease.
Description: A polyclonal antibody against RMI1. Recognizes RMI1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA
Description: A polyclonal antibody against RMI1. Recognizes RMI1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
Description: A polyclonal antibody against RMI1. Recognizes RMI1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA
Description: A sandwich ELISA for quantitative measurement of Canine RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Rat RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Rat RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Rat RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Porcine RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Porcine RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Porcine RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Goat RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Goat RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Goat RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Mouse RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Mouse RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Mouse RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Human RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Human RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Human RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Rabbit RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Rabbit RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Rabbit RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Monkey RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Monkey RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Monkey RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse RecQ-mediated genome instability protein 1 (RMI1) ELISA Kit
Description: A sandwich ELISA for quantitative measurement of Guinea pig RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Guinea pig RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Guinea pig RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Guinea pig RecQ mediated genome instability protein 1(RMI1) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Guinea pig RecQ mediated genome instability protein 1(RMI1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: RMI2 is a component of the BLM (RECQL3) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability. This gene is mapped to 16p13.13. RMI1 and RMI2 were present in approximately stoichiometric amounts with other BLM complex components, including topoisomerase-3-alpha (TOP3A), RPA (RPA1), and BLAP250. RMI2 also associated with RMI1 and TOP3A in a second complex. RMI1 and RMI2 interacted directly, and both were essential for stability of the BLM complex. Depletion of either RMI1 or RMI2 depleted the other protein by 80 to 90%. Chicken DT40 cells depleted of Rmi2 displayed elevated sister chromatid exchange, but other functions of the BLM complex appeared intact. Mutation analysis revealed that interaction between human RMI2 and BLM was essential for suppression of sister chromatid exchange.
Mouse RecQ-mediated genome instability protein 2 (RMI2) ELISA Kit
This observation has been validated using breast cancer datasets publicly available independent of The Cancer Genome Atlas. We focus on triple negative breast cancer subtypes to highlight potentially relevant miRNAs in these tumor subtypes. For those miRNAs were identified as potential regulators, we characterize the function of target genes affected by enrichment analysis. In two independent datasets, targets affected are not always the same, but displays a similar enriched categories, including breast cancer-related processes such as cell substrate adherens junction, regulation of cell migration, nuclear pore complex and the integrin pathway.
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