June 19, 2024

DeDaL: Cytoscape 3 app for producing and morphing data-driven and structure-driven network layouts.

BACKGROUND
Visualization and molecular profiling data analysis together with biological tissue can provide new mechanistic insight into the biological function. At present, it is possible to visualize high-throughput of data over the network layout has been determined, but they are not always suitable for the tasks of data analysis are given. A network layout based simultaneously on the network structure and associated multidimensional data may be advantageous for data visualization and analysis in some cases.

RESULTS
We develop Cytoscape application, which allows to build a biological network layout based on data from the molecular profile is imported as the values ​​of the attribute node. Dedal is 3 Cytoscape application, which uses an algorithm of linear and non-linear dimension reduction for network layout generate data-driven based on the multidimensional data (usually the expression of genes). tools Dedal some data pre-processing and post-processing layout step as a continuous morphing between two arbitrary network layout and align the network layout with respect to each other by rotating and mirroring.

The combination of all of these functions facilitate the creation of the network layout insight which represents both structural network features and patterns of correlations in multivariate data. We demonstrate the added value of the application Dedal in several practical applications, including tissue samples large protein-protein interactions.

DeDaL: Cytoscape 3 app for producing and morphing data-driven and structure-driven network layouts.
DeDaL: Cytoscape 3 app for producing and morphing data-driven and structure-driven network layouts.

Detection of miRNA regulatory effects on triple negative breast cancer transcriptome.

Identify key microRNAs (miRNAs) contributing to the origin and development of certain diseases is the focus of much recent research. We introduce here the rank-based algorithms for detecting miRNA regulatory activity in cancer tissue samples revealed that combining the measurements of gene and the expression levels of miRNA and target sequence-based prediction. This method is designed to detect modest but coordinated changes in expression of the target gene-sequence predicted based. We apply an algorithm to a cohort of 129 breast tumor and the healthy tissue and shown to be effective in identifying functional miRNAs may be involved in disease.

RMI1 Antibody

1-CSB-PA875699LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against RMI1. Recognizes RMI1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

RMI1 Antibody

1-CSB-PA019754GA01HU
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  • 150ul
  • 50ul
Description: A polyclonal antibody against RMI1. Recognizes RMI1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

RMI1 Antibody

DF12724 200ul
EUR 420

RMI1 Antibody

DF12724-100ul 100ul
EUR 280

RMI1 Antibody

DF12724-200ul 200ul
EUR 350

RMI1 Antibody

E94991 100μg
EUR 255
Description: Available in various conjugation types.

RMI1 Antibody

E308764 200ul
EUR 275
Description: Available in various conjugation types.

RMI1 Antibody

CAC09814-100ug 100ug
EUR 314

RMI1 Antibody

CAC09814-50ug 50ug
EUR 199.2

RMI1 antibody

70R-19909 50 ul
EUR 289
Description: Rabbit polyclonal RMI1 antibody

RMI1 antibody

70R-5555 50 ug
EUR 467
Description: Rabbit polyclonal RMI1 antibody

RMI1 Antibody

GWB-MQ423I 50ug Ask for price

RMI1 Antibody

MBS7000931-005mg 0.05mg
EUR 190

RMI1 Antibody

MBS7000931-01mg 0.1mg
EUR 270

RMI1 Antibody

MBS7000931-5x01mg 5x0.1mg
EUR 1205

RMI1 Antibody

MBS8505773-01mg 0.1mg
EUR 325

RMI1 Antibody

MBS8505773-01mLAF405L 0.1mL(AF405L)
EUR 565

RMI1 Antibody

MBS8505773-01mLAF405S 0.1mL(AF405S)
EUR 565

RMI1 Antibody

MBS8505773-01mLAF610 0.1mL(AF610)
EUR 565

RMI1 Antibody

MBS8505773-01mLAF635 0.1mL(AF635)
EUR 565

RMI1 Antibody

MBS9611475-01mL 0.1mL
EUR 260

RMI1 Antibody

MBS9611475-02mL 0.2mL
EUR 305

RMI1 Antibody

MBS9611475-5x02mL 5x0.2mL
EUR 1220

RMI1 (untagged)-Human RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1)

SC322629 10 µg Ask for price

RMI1 (untagged)-Human RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1)

SC111381 10 µg Ask for price

RMI1 (GFP-tagged) - Human RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1)

RG208030 10 µg Ask for price

RMI1 (Myc-DDK-tagged)-Human RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1)

RC208030 10 µg Ask for price

RMI1 Rabbit pAb

A4991-100ul 100 ul
EUR 369.6

RMI1 Rabbit pAb

A4991-200ul 200 ul
EUR 550.8

RMI1 Rabbit pAb

A4991-20ul 20 ul
EUR 219.6

RMI1 Rabbit pAb

A4991-50ul 50 ul
EUR 267.6

RMI1 cDNA Clone

MBS1276534-001mgPlasmid02mLGlycerolStock 0.01mgPlasmid+0.2mLGlycerol-Stock
EUR 200

RMI1 cDNA Clone

MBS1276534-5x001mgPlasmid5x02mLGlycerolStock 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock
EUR 855

RMI1 Rabbit pAb

A4991 100μL
EUR 262.15

RMI1 siRNA (Human)

MBS8214817-15nmol 15nmol
EUR 405

RMI1 siRNA (Human)

MBS8214817-30nmol 30nmol
EUR 565

RMI1 siRNA (Human)

MBS8214817-5x30nmol 5x30nmol
EUR 2450

RMI1 siRNA (Mouse)

MBS8208894-15nmol 15nmol
EUR 405

RMI1 siRNA (Mouse)

MBS8208894-30nmol 30nmol
EUR 565

RMI1 siRNA (Mouse)

MBS8208894-5x30nmol 5x30nmol
EUR 2450

anti- RMI1 antibody

FNab07321 100µg
EUR 702
Description: Antibody raised against RMI1

RMI1 cloning plasmid

CSB-CL875699HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the RMI1 gene.

RMI1 Blocking Peptide

33R-1953 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of RMI1 antibody, catalog no. 70R-5555

RMI1 Blocking Peptide

DF12724-BP 1mg
EUR 234

RMI1 Blocking Peptide

MBS9621428-1mg 1mg
EUR 380

RMI1 Blocking Peptide

MBS9621428-5x1mg 5x1mg
EUR 1650

RMI1 Polyclonal Antibody

A67578
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  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

RMI1 Polyclonal Antibody

30629 100ul
EUR 439

RMI1 Polyclonal Antibody

30629-100ul 100ul
EUR 302.4

RMI1 Polyclonal Antibody

30629-50ul 50ul
EUR 224.4

RMI1 Polyclonal Antibody

E-AB-92626-120uL 120uL
EUR 320
Description: Unconjugated

RMI1 Polyclonal Antibody

E-AB-92626-200uL 200uL
EUR 530
Description: Unconjugated

RMI1 Polyclonal Antibody

E-AB-92626-60uL 60uL
EUR 200
Description: Unconjugated

RMI1 Polyclonal Antibody

E-AB-92626-each each Ask for price
Description: Unconjugated

RMI1 Polyclonal Antibody

MBS129174-002mL 0.02mL
EUR 200

RMI1 Polyclonal Antibody

MBS129174-005mL 0.05mL
EUR 255

RMI1 Polyclonal Antibody

MBS129174-01mL 0.1mL
EUR 345

RMI1 Polyclonal Antibody

MBS129174-02mL 0.2mL
EUR 545

RMI1 Polyclonal Antibody

MBS129174-5x02mL 5x0.2mL
EUR 2265

RMI1 Polyclonal Antibody

A72829 50 μl
EUR 408

RMI1 Polyclonal Antibody

MBS9433760-005mL 0.05mL
EUR 300

RMI1 Polyclonal Antibody

MBS9433760-01mL 0.1mL
EUR 390

RMI1 Polyclonal Antibody

MBS9433760-5x01mL 5x0.1mL
EUR 1610

Rmi1 (untagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 2, (10ug)

MC219739 10 µg Ask for price

Rmi1 (untagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 1, (10ug)

MC219740 10 µg Ask for price

Rmi1 (Myc-DDK-tagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 1

MR223479 10 µg Ask for price

Rmi1 (Myc-DDK-tagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 2

MR209446 10 µg Ask for price

Rmi1 (GFP-tagged) - Mouse RMI1 RecQ mediated genome instability 1 homolog (S. cerevisiae) (Rmi1) transcript variant 1, (10ug)

MG223479 10 µg Ask for price

Mouse Rmi1 ELISA KIT

ELI-38860m 96tests
EUR 736

Human RMI1 ELISA KIT

EF002488 96tests
EUR 566

Human RMI1 ELISA KIT

ELI-14504h 96tests
EUR 696

Mouse Rmi1 ELISA Kit

EF015197 96tests
EUR 566

Bovine RMI1 ELISA Kit

EF011502 96tests
EUR 566

Bovine RMI1 ELISA KIT

ELI-20347b 96tests
EUR 796

Chicken RMI1 ELISA Kit

EF012342 96tests
EUR 566

Chicken RMI1 ELISA KIT

ELI-20348c 96tests
EUR 796

RMI1 Antibody (N-term)

MBS9201450-008mL 0.08mL
EUR 210

RMI1 Antibody (N-term)

MBS9201450-04mL 0.4mL
EUR 430

RMI1 Antibody (N-term)

MBS9201450-5x04mL 5x0.4mL
EUR 1910

Mouse RMI1 shRNA Plasmid

20-abx978212
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  • 150 µg
  • 300 µg

Human RMI1 shRNA Plasmid

20-abx962721
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  • 150 µg
  • 300 µg

Human RMI1 Protein Lysate

MBS8418638-002mg 0.02mg
EUR 365

Human RMI1 Protein Lysate

MBS8418638-5x002mg 5x0.02mg
EUR 1410

RMI1 Antibody, HRP conjugated

1-CSB-PA875699LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against RMI1. Recognizes RMI1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

RMI1 Antibody; HRP conjugated

MBS7001280-005mg 0.05mg
EUR 190

RMI1 Antibody; HRP conjugated

MBS7001280-01mg 0.1mg
EUR 270

RMI1 Antibody; HRP conjugated

MBS7001280-5x01mg 5x0.1mg
EUR 1205

RMI1 Antibody, FITC conjugated

1-CSB-PA875699LC01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against RMI1. Recognizes RMI1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

RMI1 Antibody; FITC conjugated

MBS7006670-005mg 0.05mg
EUR 190

RMI1 Antibody; FITC conjugated

MBS7006670-01mg 0.1mg
EUR 270

RMI1 Antibody; FITC conjugated

MBS7006670-5x01mg 5x0.1mg
EUR 1205

RMI1 Recombinant Protein (Human)

RP026503 100 ug Ask for price

RMI1 Recombinant Protein (Mouse)

RP168335 100 ug Ask for price

RMI1 Recombinant Protein (Mouse)

RP168338 100 ug Ask for price

Rmi1 (GFP-tagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S

MG209446 10 µg Ask for price

RMI1 Antibody, Biotin conjugated

1-CSB-PA875699LD01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against RMI1. Recognizes RMI1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

RMI1 Antibody; Biotin conjugated

MBS7000698-005mg 0.05mg
EUR 190

RMI1 Antibody; Biotin conjugated

MBS7000698-01mg 0.1mg
EUR 270

RMI1 Antibody; Biotin conjugated

MBS7000698-5x01mg 5x0.1mg
EUR 1205

RMI1 Polyclonal Conjugated Antibody

C30629 100ul
EUR 476.4

RMI1 Polyclonal Conjugated Antibody

MBS9441805-01mLAF350 0.1mL(AF350)
EUR 480

RMI1 Polyclonal Conjugated Antibody

MBS9441805-01mLAF405 0.1mL(AF405)
EUR 480

RMI1 Polyclonal Conjugated Antibody

MBS9441805-01mLAF488 0.1mL(AF488)
EUR 480

RMI1 Polyclonal Conjugated Antibody

MBS9441805-01mLAF555 0.1mL(AF555)
EUR 480

RMI1 Polyclonal Conjugated Antibody

MBS9441805-01mLBiotin 0.1mL(Biotin)
EUR 480

Lenti ORF particles, RMI1 (mGFP-tagged) - Human RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1), 200ul, >10^7 TU/mL

RC208030L2V 200 µl Ask for price

Lenti ORF particles, RMI1 (mGFP-tagged) - Human RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1), 200ul, >10^7 TU/mL

RC208030L4V 200 µl Ask for price

Lenti ORF clone of Rmi1 (mGFP-tagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 1

MR223479L4 10 µg Ask for price

Lenti ORF clone of Rmi1 (mGFP-tagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 2

MR209446L4 10 µg Ask for price

Lenti ORF particles, Rmi1 (GFP-tagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 1, 20

MR223479L4V 200 µl Ask for price

Lenti ORF particles, Rmi1 (GFP-tagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 2, 20

MR209446L4V 200 µl Ask for price

Lenti ORF particles, Rmi1 (Myc-DDK-tagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 1

MR223479L3V 200 µl Ask for price

Lenti ORF particles, Rmi1 (Myc-DDK-tagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 2

MR209446L3V 200 µl Ask for price

RMI1 ORF Vector (Human) (pORF)

ORF008835 1.0 ug DNA
EUR 114

Rmi1 ORF Vector (Mouse) (pORF)

ORF056113 1.0 ug DNA
EUR 607.2

Rmi1 ORF Vector (Mouse) (pORF)

ORF056114 1.0 ug DNA
EUR 607.2

BLAP75 (RMI1) (NM_024945) Human Recombinant Protein

PROTQ9H9A7 20ug
EUR 1249
Description: Purified recombinant protein of Homo sapiens RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1)

Lenti ORF particles, RMI1 (Myc-DDK tagged) - Human RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1), 200ul, >10^7 TU/mL

RC208030L1V 200 µl Ask for price

Lenti ORF particles, RMI1 (Myc-DDK tagged) - Human RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1), 200ul, >10^7 TU/mL

RC208030L3V 200 µl Ask for price

Lenti ORF clone of Rmi1 (Myc-DDK-tagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 1

MR223479L3 10 µg Ask for price

Lenti ORF clone of Rmi1 (Myc-DDK-tagged) - Mouse RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), transcript variant 2

MR209446L3 10 µg Ask for price

Human RMI1 Protein Lysate 20ug

IHURMI1PLLY20UG each
EUR 213
Description: Human RMI1 Protein Lysate 20ug

RMI1 Peptide - N-terminal region

MBS3233127-01mg 0.1mg
EUR 180

RMI1 Peptide - N-terminal region

MBS3233127-5x01mg 5x0.1mg
EUR 730

RMI1 antibody - N-terminal region

MBS3208164-01mL 0.1mL
EUR 455

RMI1 antibody - N-terminal region

MBS3208164-5x01mL 5x0.1mL
EUR 1995

Recombinant Human RMI1, GST-tagged

RMI1-2319H 25ug
EUR 255.2
Description: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.

OCOA08048-20UG - RMI1 Protein Lysate

OCOA08048-20UG 20ug
EUR 169

RMI1 Over-expression Lysate Product

GWB-28B18E 0.1 mg Ask for price

RMI1 Polyclonal Antibody, HRP Conjugated

A67579
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  • 100 µg
  • 50 ul
  • 100 ul

RMI1 Polyclonal Antibody, FITC Conjugated

A67580
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  • Ask for price
  • 100 µg
  • 50 ul
  • 100 ul

RMI1 Polyclonal Antibody, Biotin Conjugated

A67581
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  • Ask for price
  • Ask for price
  • 100 µg
  • 50 ul
  • 100 ul

BLAP75 (RMI1) (NM_024945) Human Over-expression Lysate

LS080010 100ug
EUR 628
Description: Transient overexpression lysate of RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1)

RMI1 sgRNA CRISPR Lentivector set (Human)

K1827701 3 x 1.0 ug
EUR 406.8

Rmi1 sgRNA CRISPR Lentivector set (Mouse)

K4476601 3 x 1.0 ug
EUR 406.8

RMI1 Antibody (N-term) Blocking Peptide

MBS9222072-INQUIRE INQUIRE Ask for price

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75)

MBS6012524-02mL 0.2(mL
EUR 695

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75)

MBS6012524-5x02mL 5x0.2mL
EUR 2975

Rmi1 3'UTR GFP Stable Cell Line

TU167918 1.0 ml Ask for price

Rmi1 3'UTR GFP Stable Cell Line

TU269470 1.0 ml Ask for price

RMI1 3'UTR GFP Stable Cell Line

TU069953 1.0 ml
EUR 1672.8

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75) (AP)

MBS6342335-02mL 0.2mL
EUR 980

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75) (AP)

MBS6342335-5x02mL 5x0.2mL
EUR 4250

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75) (PE)

MBS6342345-02mL 0.2mL
EUR 980

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75) (PE)

MBS6342345-5x02mL 5x0.2mL
EUR 4250

Lenti ORF clone of Human RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1), mGFP tagged

RC208030L2 10 µg Ask for price

Lenti ORF clone of Human RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (RMI1), mGFP tagged

RC208030L4 10 µg Ask for price

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75) (APC)

MBS6342336-02mL 0.2mL
EUR 980

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75) (APC)

MBS6342336-5x02mL 5x0.2mL
EUR 4250

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75) (Biotin)

MBS6342337-02mL 0.2mL
EUR 980

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75) (Biotin)

MBS6342337-5x02mL 5x0.2mL
EUR 4250

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75) (FITC)

MBS6342338-02mL 0.2mL
EUR 980

RMI1, NT (RMI1, C9orf76, RecQ-mediated genome instability protein 1, BLM-associated protein of 75kD, FAAP75) (FITC)

MBS6342338-5x02mL 5x0.2mL
EUR 4250

RMI1 Protein Vector (Human) (pPM-C-HA)

PV035339 500 ng
EUR 394.8

RMI1 Protein Vector (Mouse) (pPM-C-HA)

PV224452 500 ng
EUR 723.6

RMI1 Protein Vector (Mouse) (pPM-C-HA)

PV224456 500 ng
EUR 723.6

RMI1 3'UTR Luciferase Stable Cell Line

TU019953 1.0 ml
EUR 1672.8

Rmi1 3'UTR Luciferase Stable Cell Line

TU117918 1.0 ml Ask for price

RMI1 Protein Vector (Human) (pPB-C-His)

PV035337 500 ng
EUR 394.8

RMI1 Protein Vector (Human) (pPB-N-His)

PV035338 500 ng
EUR 394.8

RMI1 Protein Vector (Human) (pPM-C-His)

PV035340 500 ng
EUR 394.8

RMI1 Protein Vector (Mouse) (pPB-C-His)

PV224450 500 ng
EUR 723.6

RMI1 Protein Vector (Mouse) (pPB-N-His)

PV224451 500 ng
EUR 723.6

RMI1 Protein Vector (Mouse) (pPM-C-His)

PV224453 500 ng
EUR 723.6

RMI1 Protein Vector (Mouse) (pPB-C-His)

PV224454 500 ng
EUR 723.6

RMI1 Protein Vector (Mouse) (pPB-N-His)

PV224455 500 ng
EUR 723.6

This observation has been validated using breast cancer datasets publicly available independent of The Cancer Genome Atlas. We focus on triple negative breast cancer subtypes to highlight potentially relevant miRNAs in these tumor subtypes. For those miRNAs were identified as potential regulators, we characterize the function of target genes affected by enrichment analysis. In two independent datasets, targets affected are not always the same, but displays a similar enriched categories, including breast cancer-related processes such as cell substrate adherens junction, regulation of cell migration, nuclear pore complex and the integrin pathway.

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